Description
MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a Ki value of 0.015 µM and aKd value of 0.036 µM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells[1]