ASTM D8421-22 Standard Test Method for Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Matrices by Co-solvation Followed by Analysis Using the Shimadzu LCMS-8060NX

Monday, May 6, 2024

ASTM International published ASTM D84211 for the analysis of 44 per- and polyfluorinated alkyl substances and 24 labeled isotopes in non-potable water samples. This method extracts the substances in a 1+1 ratio of sample and methanol, filters and then measures the targeted compounds using external standard calibration liquid chromatography-tandem mass spectrometry (LC/MS/MS). The minimum reporting limit is 10 ng/L with an analytical range of 10 – 400 ng/L for most compounds. The method requires standard solutions be prepared by the laboratory from neat compounds. To save a laboratory’s time and effort from preparing stock standards individually, we optimized the method using commercially available native and labeled calibration standard mixes. Additionally, we optimized chromatography, achieving better peak shape for early-eluting compounds, such as PFBA and PFPrA.

This application news summarizes the performance of the Shimadzu LCMS-8060NX Liquid Chromatography Mass Spectrometer (LC/MS/MS) for all analytes listed in ASTM D8421. Results meet or exceed the requirements outlined in the method. Download now to learn more.

Download Now

    If you are already registered or have requested a quote before, and your contact information will be filled out for you.

  • Please enter your first and last name.

  • Please enter the name of the company or institution you work at.

  • Please enter your mailing address.

  • Please enter the e-mail address you would like to be contacted at.

  • By submitting this form, you consent to Labcompare storing your email address and contact information and transmitting your contact information to the content sponsor. You may request to be removed at any time.