Coronaviruses are single-stranded RNA viruses that belong to the Coronaviridae family. The SARS-CoV-2 classification as a pandemic virus has made the need for diagnostic tests and vaccine development high priority.
Covid-19 consists of four major proteins including a protruding glycoprotein (spike), membrane, envelope, and nucleocapsid. The spike glycoprotein can mediate entrance into the human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2). The spike glycoprotein includes two regions, S1 and S2, where S1 is the site of host cell receptor binding and S2 is for membrane fusion. The spike glycoprotein is now the key target for vaccines, therapeutic antibodies and diagnostics.
AMSBIO is supplying high quality 2019-nCoV full length S protein, S1 protein and human ACE2 protein based on the HEK293 human cell expression platform. Binding activity of these products has been verified by Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) technologies.
In addition, antibodies are available including: