Ströhl initially got the idea a few years ago. "I built the very first prototype by hand. It took forever, since I had to do everything manually. Therefore, I was very relieved when it yielded results and provided great images," said the researcher. Credit: Kjetil Rydland/UiT
Researchers from UiT The Arctic University of Norway and the University Hospital of North Norway (UNN) have developed what they are referring to as the “next-generation microscope.” The new technology can take pictures of much larger samples than before, while living and working in a more natural environment.
The new microscope is a so-called multifocus microscope. The patented technology provides 3D images where researchers can study the smallest details from several angles, clearly and visibly, sorted into different layers and all layers are in focus.
“With our technology, we can manage around 100 full frames per second. And we believe it is possible to increase this number. This is just what we have demonstrated with our prototype," said Florian Ströhl, researcher at UiT.
In a test, Ströhl and the research team looked at stem cells manipulated to mimic heart cells. The cell tissue, about 1 cm in size, is normally difficult to test since the cells beat and are in constant motion, along with the fact that the sample is too large to study with traditional microscopes.
However, the multifocus microscope worked well, say the researchers.
“You have this pumping lump of meat in a bowl, which you want to take microscope pictures of. You want to view at the very smallest parts of this, and you want super high resolution. We have achieved this with the new microscope," said Ströhl.
Kenneth Bowitz Larsen heads a large laboratory with advanced microscopes that are used by all the research groups at the Faculty of Health at UiT. He has tested the new microscope, and is optimistic.
“It is very photosensitive, and it can depict the specimen in various focuses. It can work its way through the sample and you can view both high and low. And it happens so fast that it can practically be seen in real time. It's an extremely fast microscope," said Larsen.
According to Larsen, the tests so far show that this works well, and he believes this type of microscope can eventually be used on all types of samples where you look at living things that move.
The prototype of the microscope is currently operational. The researchers are currently working on creating an upgraded version that is easier to use, so that more people are able to operate and use the microscope. In the meantime, the prototype will be made available to local partners who can benefit from the new technology.