| Description | Available in a 3?µm particle size and formats such as 4.6?×?150?mm, 4.6?×?300?mm, 7.8?×?150?mm, and 7.8?×?300?mm, the Waters GTxResolve SEC?1000?Å Column is designed for high recovery analysis of large gene therapy biomolecules including Nucleic Acids & LNPs. Its low adsorption MaxPeak™ HPS hardwareAvailable in a 3?µm particle size and formats such as 4.6?×?150?mm, 4.6?×?300?mm, 7.8?×?150?mm, and 7.8?×?300?mm, the Waters GTxResolve SEC?1000?Å Column is designed for high recovery analysis of large gene therapy biomolecules including Nucleic Acids & LNPs. Its low adsorption MaxPeak™ HPS hardware and bridged ethylene HO PEO particles provide long column lifetimes, reduced secondary interactions, and improved MALS sensitivity. Compared to traditional 5?µm, 1000?Å SEC columns, the 3?µm GTxResolve 1000?Å packing delivers enhanced resolution and reproducibility for biomolecules in the 200–800?Å size range, enabling clearer separation of aggregates, monomers, and ejected transgenes. This improvement supports more confident assessment of mRNA integrity, LNP heterogeneity, and viral vector impurity profiles.... Read More | Recommended C18 for use with the AccQ•Tag Ultra amino acid analysis solution:
AccQ•Tag Ultra C18, 1.7 µm, 2.1 x 100 mm Column (SKU: 186003837) | Achieve improved peak shape using a novel 3 µm affinity particle and MaxPeak Premier Technology. The 2.1 x 20 mm Protein A column provides greater sensitivity and enable Protein A - MS methods while the 3.9 x 5 mm column provides reproducible robustness. To get even more out of every run, Achieve improved peak shape using a novel 3 µm affinity particle and MaxPeak Premier Technology. The 2.1 x 20 mm Protein A column provides greater sensitivity and enable Protein A - MS methods while the 3.9 x 5 mm column provides reproducible robustness. To get even more out of every run, employ a simplified, direct-connect workflow using a single-pump UHPLC system for an easier, more reliable 2D ProA-SEC setup than traditional switching-valve, dual-pump, and loop-based methods. Gain greater titer sensitivity and improved lower limits of quantitation (LLOQ) for mAbs, multi-specifics, and other advanced antibody modalities. Enable earlier access to results in upstream processing and drive faster method optimization in downstream development to support critical applications.... Read More | Available in a 3?µm particle size and formats: 4.6 × 150?mm, 4.6 × 300?mm, 7.8 × 150?mm, 7.8 × 300?mm the Waters GTxResolve 2000?Å SEC Column is designed for high recovery analysis of large gene therapy biomolecules including LNPs, plasmids, and viral vectors. Its low adsorption MaxPeak™ Premier Available in a 3?µm particle size and formats: 4.6 × 150?mm, 4.6 × 300?mm, 7.8 × 150?mm, 7.8 × 300?mm the Waters GTxResolve 2000?Å SEC Column is designed for high recovery analysis of large gene therapy biomolecules including LNPs, plasmids, and viral vectors. Its low adsorption MaxPeak™ Premier hardware and bridged ethylene HO PEO particles ensure long column lifetimes, low secondary interactions, and improved MALS sensitivity. Compared to traditional 5?µm, 2000?Å SEC columns, the 3?µm GTxResolve 2000?Å packing delivers superior resolution and reproducibility for megadalton sized species, enabling clearer separation of aggregates, monomers, and structural variants. This improvement supports more confident assessment of plasmid integrity, LNP heterogeneity, and viral vector impurities.... Read More | Available in a 2.5?µm particle size and formats including 4.6?×?150?mm, 4.6?×?300?mm, 7.8?×?150?mm, and 7.8?×?300?mm, the Waters GTxResolve BEH SEC?450?Å Column provides high resolution, fast size variant analysis tailored for AAVs and small VLPs. Its hydrophilic MaxPeak™ High Performance Surface Available in a 2.5?µm particle size and formats including 4.6?×?150?mm, 4.6?×?300?mm, 7.8?×?150?mm, and 7.8?×?300?mm, the Waters GTxResolve BEH SEC?450?Å Column provides high resolution, fast size variant analysis tailored for AAVs and small VLPs. Its hydrophilic MaxPeak™ High Performance Surface hardware minimizes secondary interactions, ensuring robust, serotype independent workflows and excellent sample recovery.
The 2.5?µm BEH particle design delivers industry leading resolution without analyte shearing, enabling ideal separation of AAV monomers and aggregates... Read More |