| Description | Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and analyzing mammalian cells. Tracking the formation of a colony from a single cell is effortless as barcoded plates are tracked over time. Automated acquisition and analysis provides accurate, objective, and consistent results.
With high-resolution white light imaging, the CloneSelect Imager provides automated confluence, monoclonality assurance and industry leading acquisition times with the ability to image a 96-well plate in under two minutes.
The CloneSelect Imager FL features high contrast multichannel fluorescent and white light imaging that allows for accurate single cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.
Features :
- White light and fluorescent imaging -
Image every well in every plate with rapid acquisition times with label-free white light. Multichannel fluorescence imaging provides additional confidence of monoclonality and comparative confluence assays (red vs green). -
Data tools to accelerate research timelines -
The software automatically calculates confluence measurements and generates growth curves, heatmaps, and image montages. Measurements for every well are automatically tracked over time. Streamline multiple steps (imaging, sample tracking, data analysis and report generation) in the cell line development workflow for IND filing. -
Quickly image a variety of plate formats and cell types -
Image a 96-well plate in under two minutes. Compatible with adherent or settled suspension cell types such as CHO, HEK, hybridomas, iPSCs, and many other cell types. -
Intelligent analysis with easy-to-use software -
The software automatically calculates confluence for each imaging time point. Growth curve, image montage, total growth, and mean rate are generated automatically and are exportable. Guided software user interface allows for simple 1-hour training. -
High-resolution images -
High-speed fluorescence and high-resolution white light imaging with accurate detection of single cells including debris. Image visualization and data tracking over multiple days. -
Custom automation options -
The Automation and Customization Team offers a variety of custom services from robotic plate loading to fully automated workstations with liquid handling and incubation. We have built out custom automated work cells with the CloneSelect Imager for iPSC workflows, full assay systems and drug toxicity and characterization research.
... Read More | Sets the enduring standard for microplate analysis using filters for end-point absorbance measurements.
The EMax® Endpoint ELISA Microplate Reader from Molecular Devices, one of the pioneers in microplate detection, offers a ruggedly simple approach to dedicated endpoint assays. A staggeringSets the enduring standard for microplate analysis using filters for end-point absorbance measurements.
The EMax® Endpoint ELISA Microplate Reader from Molecular Devices, one of the pioneers in microplate detection, offers a ruggedly simple approach to dedicated endpoint assays. A staggering mean time between failure (MTBF) of 20,000 hours is achieved by 97 independent and stationary fiber optics so that the microplate remains stationary during the entire reading cycle, reducing the number of moving parts. No optical alignment needed during the lifetime of the instrument!
Through sequential, single-well illumination, 100% of the available light is directed to each well through the optical fibers to achieve linearity to higher optical densities (ODs) and optimal signal-to-noise ratios. At 5 seconds to read a 96-well endpoint assay, the EMax Microplate Reader has both the speed and performance to carry a heavy workload.
The EMax Microplate Reader is capable of reading up to two wavelengths at a time in the visible wavelength spectrum (400nm-750nm), with 4 filter choices included at time of purchase. Additional high-quality filters to supplement your assay wavelength range requirements are available directly from Molecular Devices.
EMax Microplate Readers can be operated as a stand-alone instrument and is also supplied with SoftMax® Pro Data Acquistion & Analysis Software, Molecular Devices' industry leading all-in-one data acquisition and analysis software.
Features - Solid Performance for Dedicated Absorbance
- Enabling Features
- Read up to 2 wavelengths in endpoint absorbance for 96-well plates.
- Mix samples in microplate wells by user-programmable Automix feature.
- Operate without an attached computer using the onboard microprocessor.
- Add assay flexibility with additional filters.
- Comprehensive Reader Validation
... Read More | Multi-wavelength measurement without filters.
The Gemini™ XPS and EM Microplate Readers with dual monochromators provide a flexible environment to determine the optimal excitation and emission settings for fluorescence intensity assays. Multiple-point well scanning optimizes cell-based assay Multi-wavelength measurement without filters.
The Gemini™ XPS and EM Microplate Readers with dual monochromators provide a flexible environment to determine the optimal excitation and emission settings for fluorescence intensity assays. Multiple-point well scanning optimizes cell-based assay sensitivity. Comparison of relative fluorescence units (RFUs) between samples is allowed by a unique calibration against an internal standard. Temperature-sensitive reactions are monitored with consistent temperature regulation from ambient to 45°C.
Top-read capability -
The top-reading Gemini XPS Microplate Reader measures fluorescence on a variety of sample formats from 6- to 384-well microplates in endpoint, kinetic, spectral scan, and well-scan modes.
Top- and bottom-read capability -
The top- and bottom-reading Gemini EM Microplate Reader measures fluorescence on a variety of sample formats from 6- to 384-well microplates in endpoint, kinetic, spectral scan, and well-scan modes.
Other features and benefits include:
- Eliminate changing out filters
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Measure more accurately
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Avoid losing high signal
... Read More | Designed specifically for the SpectraMax® i3 Multi-Mode Detection Platform, the SpectraMax® MiniMaxTM imaging cytometer option adds first-of-its-kind cellular imaging capability to a microplate reader. The upgradable option makes cytometry more accessible to a wider audience, providing researchers Designed specifically for the SpectraMax® i3 Multi-Mode Detection Platform, the SpectraMax® MiniMaxTM imaging cytometer option adds first-of-its-kind cellular imaging capability to a microplate reader. The upgradable option makes cytometry more accessible to a wider audience, providing researchers with cellular analysis capability without the need for investment in complex imaging systems. With brightfield and fluorescent imaging modes, the imaging cytometry option enables quick inspection of cells and provides insight into phenotypic changes that are important for understanding cytotoxicity, cell proliferation, and protein expression.
Features - Simple workflow: Cell and whole-well assays in a small footprint
- More data: Multi-parametric cell-based assays with brightfield and fluorescent modes
- Familiar software: Set up, image and analyze cells in a snap using SoftMax® Pro Software
- Higher sensitivity: Use fewer and or less fluorescent cells compared to whole-well measurements
- Lower variance: Normalize readings with number of cells in a well
... Read More | Enables precise and accurate detection at wavelengths in the visible spectrum without the use of filters, providing consequence-free assay flexibility.
Built around a grating monochromator, the VersaMax™ Absorbance Microplate Reader allows for selection of up to two wavelengths at a time for Enables precise and accurate detection at wavelengths in the visible spectrum without the use of filters, providing consequence-free assay flexibility.
Built around a grating monochromator, the VersaMax™ Absorbance Microplate Reader allows for selection of up to two wavelengths at a time for absorbance detection in the visible wavelength range (340 nm - 850 nm). Narrow bandwidths deliver increased accuracy and enhanced peak resolution. Never order or replace filters to optimize an assay again!
A patented multichannel optical design mimics a dual-beam spectrophotometer, measures each sample in the plate directly, and eliminates error due to variations in light output between optical fibers on other instruments for more reliable reporting. The eight-channel system delivers high precision and speed when reading 96-well microplates for single endpoint measurements and kinetic assay data gathered over time.
The VersaMax Microplate Reader is supplied with SoftMax® Pro Data Acquistion & Analysis Software, Molecular Devices' industry leading all-in-one data acquisition and analysis software. Additionally, the VersaMax Microplate Reader can be seamlessly integrated with the StakMax® Microlate Handling Stacker through the SoftMax Pro Software.
Features - Enabling Assays without Compromise
- Measuring Accurately and Reproducibly
- Comprehensive Reader Validation
- Automating with Ease
... Read More |