Liquid Handling Robotics (Automated Systems)

The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry-leading brand - combined with enhancements suggested by customers around the globe.

• Ideal for medium- to high-throughput

The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry-leading brand - combined with enhancements suggested by customers around the globe.

• Ideal for medium- to high-throughput workflows
• 25 deck positions
• 0.5 µL-1,000 µL (Multichannel) or 0.5 µL-5,000 µL (Span-8) pipetting volume ranges
• Single Multichannel head (96/384) or Span-8 pipetting with gripper

• Open platform with grid-based deck
• Internal LED light illuminates workspace
• Automated Labware Positioners (ALPs) for sample processing
• Optional enclosed version to protect samples from airborne particles
• Integrate additional devices on- or off-deck
• Configurable for specific applications

• Multichannel head (96/384) or Span-8 pipetting
• Large-volume 1 mL multichannel pipetting head
• High-access, rotating gripper with unique offset finger design
• Disposable & fixed Biomek tips, including septum piercing
• Transfer volumes from 0.5 µL - 5,000 µL
• Independent Span-8 probe calibration
• 8 channel liquid-level sensing
• Supports labware from tubes to 1,536-well microplates
• Accurate intra-well pipetting

• Easily automate existing processes and execute quick workflow changes
• Powered by icon-based software with data tracking and LIMS connectivity
• Windows 10 OS
• Extend walk-away operation with process management and scheduling software
• Automated deck framing
• Data-driven operations including hit-picking & normalization
• Light curtain safety feature
• Instrument status light bar
• DeckOptix cameras for live, remote-monitoring & on-error video capture

• Consultative workflow analysis
• Expert application & technical support
• Biomek automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows

Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to

Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to design and execute highly elaborate experiments that are on track with biological signals increasing the experiment reproducibility. Individually triggered sampling, dosing actions (e.g., adding inducer or feed solutions), or inoculation of culture wells in the BioLector XT microplate are executed on the basis of the online, real-time signals from the BioLector XT microbioreactor (biomass, pH value, dissolved oxygen concentration, experiment time, etc.) without the need to stop the shaking of the microplate inside the BioLector XT instrument.

• Measure biomass, pH value, dissolved oxygen and fluorescence online
• Increased walk-away time
• Reduce potential contamination with automation
• Reliable scale-up to benchtop fermenters
• Reproducibility and scalability of results

The system automatically draws samples, adds media and inducer solutions or inoculates the culture wells triggered by experiment time or BioLector XT microbioreactor online signals. This allows for an increased walk-away time while keeping the same level of quality output.

Take advantage of the integrated system to transform your workflow and get reproducible experiment data. The scalable results make it fast and easy to bring more products to market.

Incorporating cultivation modes with online triggers (real-time signals from the BioLector XT microbioreactor), you get the benefits of continuous operation 24/7.

Fixed Biomek tips are cleaned and decontaminated between actions reducing the potential for cross-contamination.

• High-throughput
• 45 deck positions
• 0.5 - 5,000 µL pipetting volume range
• Single or dual heads

• Spacious, open-platform with grid-based deck
• Up to 45 deck positions
• Internal LED

• High-throughput
• 45 deck positions
• 0.5 - 5,000 µL pipetting volume range
• Single or dual heads

• Spacious, open-platform with grid-based deck
• Up to 45 deck positions
• Internal LED light
• Automated Labware Positioners (ALPs) for sample processing
• Optional enclosed version to protect samples from airborne particles
• Integrate additional devices on- or off-deck
• Configurable for specific applications

• Multiple single- & dual-arm configurations with Multichannel heads (96/384/Pin tool) and/or Span-8 pipetting
• Large-volume 1 mL multichannel pipetting head
• High-access, rotating gripper(s) with unique offset finger design
• Disposable & fixed Biomek pipette tips (including septum piercing)
• Transfer volumes from 0.5 µL - 5,000 µL
• Independent Span-8 probe calibration
• 8 channel liquid-level sensing
• Supports labware from tubes to 1,536-well microplates
• Accurate intra-well pipetting

• Easily automate existing processes & execute quick workflow changes
• Powered by icon-based software with data tracking & LIMS connectivity
• Windows 10 OS
• Extend walk-away operation with process management and scheduling software
• Guided system setup
• Automated deck framing
• Data-driven method operations including hit-picking & normalization
• Light curtain safety feature
• Instrument status light bar
• DeckOptix cameras for live, remote-monitoring & on-error video capture

• Consultative workflow analysis
• Expert application & technical support
• Biomek-automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows

PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection.

• TOC, Uncompensated Conductivity and Temperature from just one

PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection.

• TOC, Uncompensated Conductivity and Temperature from just one analyzer – can be fully calibrated and validated to USP<643> and USP<645>
• Low cost of ownership – 12 month service and calibration intervals
• Root-cause analysis support – water sample automatically taken if there is a TOC excursion
• All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts

• 12 month service intervals supported by auto-switching Main and Standby UV oxidation lamps with UV output monitoring
• No chemicals/reagents required – PAT700 just uses strong UV lamps to oxidize TOC
• No peristaltic pump tubing or pump heads to replace – PAT700 uses water system pressure to push sample into measurement cell for analysis

• User can pre-program the PAT700 so that at a pre-determined TOC level, it will capture a water sample which can then be later analyzed in the QC Lab to assist root cause analysis should a TOC excursion be detected
• On-board grab sampler allows the user to take samples from different locations/use points to support root cause analysis

• PAT700 can be fully calibrated and validated for compliance to USP<643> for TOC and USP<645> for conductivity
• Complete oxidation to EP 2.2.44 requirements – the PAT700 ensures complete TOC oxidation through oxidation dynamic end-point detection
• 21CFR part 11 support – everyday users can view TOC and Conductivity results as a Guest without the ability to make any changes to the PAT700. Initial configuration and subsequent changes are protected through multi-level user name and password protection
• Dual-stream version available to demonstrate compliance both at the start and end of water loops simultaneously

• All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
• All Calibration and System Suitability standards come with certified value data and use by dates programmed into an RFID tag on the bottle itself. Following the on-screen SOPs the user is prompted to load the bottles and the PAT700 then reads the RFID tags on the bottles. If the bottles have been loaded in the wrong order, or if they have expired the PAT700 provides a warning on the touch-screen. The PAT700 then uploads certified values, carries out the test and automatically calculates a pass/fail result and provides a report.

• DO or time controlled feeding
• Fed-batch with bolus feeding
• Repeated fed-batch
• Biomass dependent sampling or dosing
• Time dependent sampling or dosing
• pH adjustments

• Biomass concentration
• pH, DO (using optodes)
• Fluorescent molecules (GFP, YFP, DsRed ...)
• NAD(P)H and riboflavins
• Process or induction time
• Working volume

• Automated upstream processing of up to 48 parallel cultivations
• Continuous operation 24 hours/day and 7 days/week
• Plug & Play disposable technology
• Design of experiments (DoE)• Detailed process understanding in short time
• Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
• Reliable scale-up to lab-fermenters
• Fast and easy data analysis
• A valuable tool for PAT and QbD
• Processing units possible (for custom made solutions)

• Automated sampling
• Automated induction
• Induction profiling
• Synchronized process manipulation
• pH profiling
• Feeding profiling
• Media preparation
• Process characterization
• High-throughput protein expression
• Automated upstream processing with microbial cultures