Liquid Handling Robotics (Automated Systems)

• Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
• Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
• Accurate and precise transfer of

• Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
• Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
• Accurate and precise transfer of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs
• Better results through direct dilution of compounds, an improvement over serial dilution methods
• Flexibility to transfer any volume of liquid from any source well to any destination well

The FluidX AcoustiX Sample Tube (FAST) was developed in collaboration with and is sold by Brooks Life Sciences for ultra-high-density sample storage. The acoustic tube offers the following benefits:

• Echo Qualified design - compatible with Echo 650T and 655T Liquid Handlers
• Preserves sample integrity from storage to screen
• Miniaturize upstream liquid handling steps to conserve sample
• Rapidly pick sets of samples for targeted screening

To meet the broad spectrum of sample throughput needs, Echo 650 Series Liquid Handlers seamlessly integrate with the highly configurable Access™ Dual Robot System accommodating a wide variety of devices and enabling a fully automated workflow.

• Configured to achieve optimal throughput for sample management workflows
• Compact and ergonomic design with docking modules, turntables, retractable shelves, and drawers
• Optional features can include environmental management to protect samples from hydration or evaporation

The Echo 655T Liquid Handler supports sample transfer directly from Echo Qualified sample tubes, enabling a fully non-contact liquid handling workflow from sample storage all the way to assay ready plates. The Echo 655T Liquid Handler is capable of transferring as little as 2.5 nL from 384-well and 1536-well microplates, and now, from sample tubes arrayed in a 96-tube format. Additionally, it transfers at the highest speed to meet the needs of high-thoughput biochemical and cell-based screening.

• Designed for biochemical and genomic sample and reagent transfer
• Improve data quality while saving on reagent costs
• Reagent reservoir for larger volume reagent transfers

• Highly precise and accurate low volume

• Designed for biochemical and genomic sample and reagent transfer
• Improve data quality while saving on reagent costs
• Reagent reservoir for larger volume reagent transfers

• Highly precise and accurate low volume transfers enabling assay miniaturization
• Builds assays 50–100 times faster than traditional liquid handlers giving the lab higher capacity from one instrument
• Suite of Echo Software Applications guide creation of complex protocols for a variety of applications
• Eliminates pipetting variances that affect assay success
• Integrates into the Labcyte Access Laboratory Workstation for increased throughput

The flexibility, speed, accuracy, and precision of the Echo 525 Liquid Handler enable researchers to build assays that are not possible with traditional liquid handlers. The use of acoustic sound energy removes the traditional boundaries of tip and pin tool based liquid handlers. Transfer variable fluid heights and viscosities from one source plate to enable rapid assay creation in one fluid transfer run. Say goodbye to fixed plate designs as the Echo Liquid Handler moves fluids from any well to any well enabling researchers to design the experimental plates they need to make new discoveries.

Assay assembly and the transfer of one reagent to many wells is simplified using the Echo Qualified Reservoir. With the capability of transferring up to 2.5 µL from each micro-well, you can build your assay without requiring an instrument change – saving time and money.

The Echo 525 Liquid Handler transfers a wide range of fluids during one transfer including distilled water, buffers, nucleic acids, and reagents containing up to 50% glycerol. With its versatile fluid range, transfer volume range, any well to any well transfer capability, and powerful applications software the Echo 525 Liquid Handler supports a wide range of genomic assay workflows:

• Gene Synthesis
• PCR and qPCR assay set-up
• RNA and DNA NGS sequencing workflows
• Sanger sequencing assay set-up
• Single-cell sample preparation

• DO or time controlled feeding
• Fed-batch with bolus feeding
• Repeated fed-batch
• Biomass dependent sampling or dosing
• Time dependent sampling or dosing
• pH adjustments

• Biomass concentration
• pH, DO (using optodes)
• Fluorescent molecules (GFP, YFP, DsRed ...)
• NAD(P)H and riboflavins
• Process or induction time
• Working volume

• Automated upstream processing of up to 48 parallel cultivations
• Continuous operation 24 hours/day and 7 days/week
• Plug & Play disposable technology
• Design of experiments (DoE)• Detailed process understanding in short time
• Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
• Reliable scale-up to lab-fermenters
• Fast and easy data analysis
• A valuable tool for PAT and QbD
• Processing units possible (for custom made solutions)

• Automated sampling
• Automated induction
• Induction profiling
• Synchronized process manipulation
• pH profiling
• Feeding profiling
• Media preparation
• Process characterization
• High-throughput protein expression
• Automated upstream processing with microbial cultures