Liquid Handling Robotics (Automated Systems)

• Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
• Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
• Accurate and precise transfer of

• Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
• Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
• Accurate and precise transfer of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs
• Better results through direct dilution of compounds, an improvement over serial dilution methods
• Flexibility to transfer any volume of liquid from any source well to any destination well

The FluidX AcoustiX Sample Tube (FAST) was developed in collaboration with and is sold by Brooks Life Sciences for ultra-high-density sample storage. The acoustic tube offers the following benefits:

• Echo Qualified design - compatible with Echo 650T and 655T Liquid Handlers
• Preserves sample integrity from storage to screen
• Miniaturize upstream liquid handling steps to conserve sample
• Rapidly pick sets of samples for targeted screening

To meet the broad spectrum of sample throughput needs, Echo 650 Series Liquid Handlers seamlessly integrate with the highly configurable Access™ Dual Robot System accommodating a wide variety of devices and enabling a fully automated workflow.

• Configured to achieve optimal throughput for sample management workflows
• Compact and ergonomic design with docking modules, turntables, retractable shelves, and drawers
• Optional features can include environmental management to protect samples from hydration or evaporation

The Echo 655T Liquid Handler supports sample transfer directly from Echo Qualified sample tubes, enabling a fully non-contact liquid handling workflow from sample storage all the way to assay ready plates. The Echo 655T Liquid Handler is capable of transferring as little as 2.5 nL from 384-well and 1536-well microplates, and now, from sample tubes arrayed in a 96-tube format. Additionally, it transfers at the highest speed to meet the needs of high-thoughput biochemical and cell-based screening.

Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to

Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to design and execute highly elaborate experiments that are on track with biological signals increasing the experiment reproducibility. Individually triggered sampling, dosing actions (e.g., adding inducer or feed solutions), or inoculation of culture wells in the BioLector XT microplate are executed on the basis of the online, real-time signals from the BioLector XT microbioreactor (biomass, pH value, dissolved oxygen concentration, experiment time, etc.) without the need to stop the shaking of the microplate inside the BioLector XT instrument.

• Measure biomass, pH value, dissolved oxygen and fluorescence online
• Increased walk-away time
• Reduce potential contamination with automation
• Reliable scale-up to benchtop fermenters
• Reproducibility and scalability of results

The system automatically draws samples, adds media and inducer solutions or inoculates the culture wells triggered by experiment time or BioLector XT microbioreactor online signals. This allows for an increased walk-away time while keeping the same level of quality output.

Take advantage of the integrated system to transform your workflow and get reproducible experiment data. The scalable results make it fast and easy to bring more products to market.

Incorporating cultivation modes with online triggers (real-time signals from the BioLector XT microbioreactor), you get the benefits of continuous operation 24/7.

Fixed Biomek tips are cleaned and decontaminated between actions reducing the potential for cross-contamination.

PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection.

• TOC, Uncompensated Conductivity and Temperature from just one

PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection.

• TOC, Uncompensated Conductivity and Temperature from just one analyzer – can be fully calibrated and validated to USP<643> and USP<645>
• Low cost of ownership – 12 month service and calibration intervals
• Root-cause analysis support – water sample automatically taken if there is a TOC excursion
• All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts

• 12 month service intervals supported by auto-switching Main and Standby UV oxidation lamps with UV output monitoring
• No chemicals/reagents required – PAT700 just uses strong UV lamps to oxidize TOC
• No peristaltic pump tubing or pump heads to replace – PAT700 uses water system pressure to push sample into measurement cell for analysis

• User can pre-program the PAT700 so that at a pre-determined TOC level, it will capture a water sample which can then be later analyzed in the QC Lab to assist root cause analysis should a TOC excursion be detected
• On-board grab sampler allows the user to take samples from different locations/use points to support root cause analysis

• PAT700 can be fully calibrated and validated for compliance to USP<643> for TOC and USP<645> for conductivity
• Complete oxidation to EP 2.2.44 requirements – the PAT700 ensures complete TOC oxidation through oxidation dynamic end-point detection
• 21CFR part 11 support – everyday users can view TOC and Conductivity results as a Guest without the ability to make any changes to the PAT700. Initial configuration and subsequent changes are protected through multi-level user name and password protection
• Dual-stream version available to demonstrate compliance both at the start and end of water loops simultaneously

• All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
• All Calibration and System Suitability standards come with certified value data and use by dates programmed into an RFID tag on the bottle itself. Following the on-screen SOPs the user is prompted to load the bottles and the PAT700 then reads the RFID tags on the bottles. If the bottles have been loaded in the wrong order, or if they have expired the PAT700 provides a warning on the touch-screen. The PAT700 then uploads certified values, carries out the test and automatically calculates a pass/fail result and provides a report.

• DO or time controlled feeding
• Fed-batch with bolus feeding
• Repeated fed-batch
• Biomass dependent sampling or dosing
• Time dependent sampling or dosing
• pH adjustments

• Biomass concentration
• pH, DO (using optodes)
• Fluorescent molecules (GFP, YFP, DsRed ...)
• NAD(P)H and riboflavins
• Process or induction time
• Working volume

• Automated upstream processing of up to 48 parallel cultivations
• Continuous operation 24 hours/day and 7 days/week
• Plug & Play disposable technology
• Design of experiments (DoE)• Detailed process understanding in short time
• Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
• Reliable scale-up to lab-fermenters
• Fast and easy data analysis
• A valuable tool for PAT and QbD
• Processing units possible (for custom made solutions)

• Automated sampling
• Automated induction
• Induction profiling
• Synchronized process manipulation
• pH profiling
• Feeding profiling
• Media preparation
• Process characterization
• High-throughput protein expression
• Automated upstream processing with microbial cultures

The TQ-Prep Workstation delivers whole blood lysis cell preparations for your flow cytometry needs time after time. A standard 32-tube carousel allows walk-away processing and perfectly complements our Navios EX flow cytometer.

The IMMUNOPREP Reagent System with

The TQ-Prep Workstation delivers whole blood lysis cell preparations for your flow cytometry needs time after time. A standard 32-tube carousel allows walk-away processing and perfectly complements our Navios EX flow cytometer.

The IMMUNOPREP Reagent System with ready-to-use CYTO-STAT tetraCHROME Monoclonal Antibody Reagents provides fast no-wash sample preparations for flow cytometric analysis, while maintaining cellular integrity and morphology.

• True walkaway operation from onboard incubation and lysis cycle processing
• User-friendly interface with a larger icon-driven touchscreen
• Maximum reliability with minimal maintenance
• The vortex system mixing ensures reproducible homogenous cell lysis
• Reagent dispensing with syringe pump system consistently provides precise and accurate volumes
• Sample throughput of up to 32 samples in only 24 minutes
• Windows 10 IOT (Internet of things) Enterprise LTSC Operating System
• Data transfer via USB

The TQ-Prep Workstation and IMMUNOPREP Reagent System together provide rapid, no-wash whole-blood sample preparation. Automation provides inter-sample and inter-laboratory consistency and reproducibility.

• Reduced number of repeat samples for cost & labor efficiencies
• Sample throughput of up to 32 samples in 24 minutes

• Maximum reliability with minimal maintenance
• Continuous real-time feedback allowing operators to follow incubation & lysing processes

• Onboard incubation and lysis cycle processing for walkaway operation
• Advanced syringe pump system for precise & accurate reagent dispensing

• Updated covers for front panel and reagent cover with improved fit
• Data privacy and security enhancements
• Updated safety certificates
• The touch screen interface has been replaced with a capacitive touch display interface
• Display icons have been resized for larger display