| Description | PAT700 TOC Analyzer Overview
PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection. - TOC, Uncompensated Conductivity and Temperature from just one
PAT700 TOC Analyzer Overview
PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection. - TOC, Uncompensated Conductivity and Temperature from just one analyzer – can be fully calibrated and validated to USP<643> and USP<645>
- Low cost of ownership – 12 month service and calibration intervals
- Root-cause analysis support – water sample automatically taken if there is a TOC excursion
- All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
PAT700 TOC Analyzer Features
Low cost of ownership
- 12 month service intervals supported by auto-switching Main and Standby UV oxidation lamps with UV output monitoring
- No chemicals/reagents required – PAT700 just uses strong UV lamps to oxidize TOC
- No peristaltic pump tubing or pump heads to replace – PAT700 uses water system pressure to push sample into measurement cell for analysis
Root-cause analysis support
- User can pre-program the PAT700 so that at a pre-determined TOC level, it will capture a water sample which can then be later analyzed in the QC Lab to assist root cause analysis should a TOC excursion be detected
- On-board grab sampler allows the user to take samples from different locations/use points to support root cause analysis
Improved compliance
- PAT700 can be fully calibrated and validated for compliance to USP<643> for TOC and USP<645> for conductivity
- Complete oxidation to EP 2.2.44 requirements – the PAT700 ensures complete TOC oxidation through oxidation dynamic end-point detection
- 21CFR part 11 support – everyday users can view TOC and Conductivity results as a Guest without the ability to make any changes to the PAT700. Initial configuration and subsequent changes are protected through multi-level user name and password protection
- Dual-stream version available to demonstrate compliance both at the start and end of water loops simultaneously
Reduced training burden – no manual calculations/data entry
- All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
- All Calibration and System Suitability standards come with certified value data and use by dates programmed into an RFID tag on the bottle itself. Following the on-screen SOPs the user is prompted to load the bottles and the PAT700 then reads the RFID tags on the bottles. If the bottles have been loaded in the wrong order, or if they have expired the PAT700 provides a warning on the touch-screen. The PAT700 then uploads certified values, carries out the test and automatically calculates a pass/fail result and provides a report.
... Read More | The most powerful and comprehensive Biomek available.
- High-throughput
- 45 deck positions
- 0.5 - 5,000 µL pipetting volume range
- Single or dual heads
Biomek i7 Automated Workstation Features
Versatile Workspace
- Spacious, open-platform with grid-based deck
- Up to 45 deck positions
- Internal LED
The most powerful and comprehensive Biomek available.
- High-throughput
- 45 deck positions
- 0.5 - 5,000 µL pipetting volume range
- Single or dual heads
Biomek i7 Automated Workstation Features
Versatile Workspace
- Spacious, open-platform with grid-based deck
- Up to 45 deck positions
- Internal LED light
- Automated Labware Positioners (ALPs) for sample processing
- Optional enclosed version to protect samples from airborne particles
- Integrate additional devices on- or off-deck
- Configurable for specific applications
Flexible Pipetting and Workflow Management
- Multiple single- & dual-arm configurations with Multichannel heads (96/384/Pin tool) and/or Span-8 pipetting
- Large-volume 1 mL multichannel pipetting head
- High-access, rotating gripper(s) with unique offset finger design
- Disposable & fixed Biomek pipette tips (including septum piercing)
- Transfer volumes from 0.5 µL - 5,000 µL
- Independent Span-8 probe calibration
- 8 channel liquid-level sensing
- Supports labware from tubes to 1,536-well microplates
- Accurate intra-well pipetting
Simple System Operation
- Easily automate existing processes & execute quick workflow changes
- Powered by icon-based software with data tracking & LIMS connectivity
- Windows 10 OS
- Extend walk-away operation with process management and scheduling software
- Guided system setup
- Automated deck framing
- Data-driven method operations including hit-picking & normalization
- Light curtain safety feature
- Instrument status light bar
- DeckOptix cameras for live, remote-monitoring & on-error video capture
Application-focused Solutions
- Consultative workflow analysis
- Expert application & technical support
- Biomek-automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows
... Read More | The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter technologies into one advanced platform that empowers lab managers with a far more effective, high-throughput method—offering increased confidence that promising clones don’t get overlooked in the process of The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter technologies into one advanced platform that empowers lab managers with a far more effective, high-throughput method—offering increased confidence that promising clones don’t get overlooked in the process of consistently selecting the best.
- High-throughput clone screening in cell line development
- Automated, walk-away operation
- All results in one software
- pH-controlled fed-batch cultivation of 96 parallel clones with individual gassing
- On-deck cell count, viability and antibody titer analysis
- Fully integrated system
... Read More | Echo 650 Series Acoustic Liquid Handler Features
Key Benefits
- Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
- Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
- Accurate and precise transfer of
Echo 650 Series Acoustic Liquid Handler Features
Key Benefits
- Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
- Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
- Accurate and precise transfer of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs
- Better results through direct dilution of compounds, an improvement over serial dilution methods
- Flexibility to transfer any volume of liquid from any source well to any destination well
Acoustic Sample Tube Management
The FluidX AcoustiX Sample Tube (FAST) was developed in collaboration with and is sold by Brooks Life Sciences for ultra-high-density sample storage. The acoustic tube offers the following benefits: - Echo Qualified design - compatible with Echo 650T and 655T Liquid Handlers
- Preserves sample integrity from storage to screen
- Miniaturize upstream liquid handling steps to conserve sample
- Rapidly pick sets of samples for targeted screening
Workflow Automation
To meet the broad spectrum of sample throughput needs, Echo 650 Series Liquid Handlers seamlessly integrate with the highly configurable Access™ Dual Robot System accommodating a wide variety of devices and enabling a fully automated workflow. - Configured to achieve optimal throughput for sample management workflows
- Compact and ergonomic design with docking modules, turntables, retractable shelves, and drawers
- Optional features can include environmental management to protect samples from hydration or evaporation
The New Sound of Sample Management
The Echo 655T Liquid Handler supports sample transfer directly from Echo Qualified sample tubes, enabling a fully non-contact liquid handling workflow from sample storage all the way to assay ready plates. The Echo 655T Liquid Handler is capable of transferring as little as 2.5 nL from 384-well and 1536-well microplates, and now, from sample tubes arrayed in a 96-tube format. Additionally, it transfers at the highest speed to meet the needs of high-thoughput biochemical and cell-based screening. ... Read More | RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system autonomously prepares media compositions, among others, from the design of experiments (DoE) tests, followed by an online-monitored high-throughput cultivation.
Furthermore, pH adjustments can be made and inducers as well as feed solutions can be added to each cultivation well according to a pre-defined schedule or triggered by online process signals. Automated sampling into various targets including a cooling station facilitates optimal process monitoring and control.
Features of the RoboLector XL
Cultivation Modes - DO or time controlled feeding
- Fed-batch with bolus feeding
- Repeated fed-batch
- Biomass dependent sampling or dosing
- Time dependent sampling or dosing
- pH adjustments
Online Trigger Signals - Biomass concentration
- pH, DO (using optodes)
- Fluorescent molecules (GFP, YFP, DsRed ...)
- NAD(P)H and riboflavins
- Process or induction time
- Working volume
Advantages - Automated upstream processing of up to 48 parallel cultivations
- Continuous operation 24 hours/day and 7 days/week
- Plug & Play disposable technology
- Design of experiments (DoE)• Detailed process understanding in short time
- Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
- Reliable scale-up to lab-fermenters
- Fast and easy data analysis
- A valuable tool for PAT and QbD
- Processing units possible (for custom made solutions)
Applications - Automated sampling
- Automated induction
- Induction profiling
- Synchronized process manipulation
- pH profiling
- Feeding profiling
- Media preparation
- Process characterization
- High-throughput protein expression
- Automated upstream processing with microbial cultures
... Read More |
| Applications | Demonstrate compliance with the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection | Genomic, drug discovery & basic research workflows | Top clone screening in Cell Line Development | Inquire | Automated sampling, automated induction, induction profiling, synchronized process manipulation, pH profiling, feeding profiling, media preparation, process characterization, high-throughput protein expression, and automated upstream processing with microbial cultures |