| Description | RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system autonomously prepares media compositions, among others, from the design of experiments (DoE) tests, followed by an online-monitored high-throughput cultivation.
Furthermore, pH adjustments can be made and inducers as well as feed solutions can be added to each cultivation well according to a pre-defined schedule or triggered by online process signals. Automated sampling into various targets including a cooling station facilitates optimal process monitoring and control.
Features of the RoboLector XL
Cultivation Modes - DO or time controlled feeding
- Fed-batch with bolus feeding
- Repeated fed-batch
- Biomass dependent sampling or dosing
- Time dependent sampling or dosing
- pH adjustments
Online Trigger Signals - Biomass concentration
- pH, DO (using optodes)
- Fluorescent molecules (GFP, YFP, DsRed ...)
- NAD(P)H and riboflavins
- Process or induction time
- Working volume
Advantages - Automated upstream processing of up to 48 parallel cultivations
- Continuous operation 24 hours/day and 7 days/week
- Plug & Play disposable technology
- Design of experiments (DoE)• Detailed process understanding in short time
- Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
- Reliable scale-up to lab-fermenters
- Fast and easy data analysis
- A valuable tool for PAT and QbD
- Processing units possible (for custom made solutions)
Applications - Automated sampling
- Automated induction
- Induction profiling
- Synchronized process manipulation
- pH profiling
- Feeding profiling
- Media preparation
- Process characterization
- High-throughput protein expression
- Automated upstream processing with microbial cultures
... Read More | BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration
Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration
Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to design and execute highly elaborate experiments that are on track with biological signals increasing the experiment reproducibility. Individually triggered sampling, dosing actions (e.g., adding inducer or feed solutions), or inoculation of culture wells in the BioLector XT microplate are executed on the basis of the online, real-time signals from the BioLector XT microbioreactor (biomass, pH value, dissolved oxygen concentration, experiment time, etc.) without the need to stop the shaking of the microplate inside the BioLector XT instrument. - Measure biomass, pH value, dissolved oxygen and fluorescence online
- Increased walk-away time
- Reduce potential contamination with automation
- Reliable scale-up to benchtop fermenters
- Reproducibility and scalability of results
BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration Features
Automation
The system automatically draws samples, adds media and inducer solutions or inoculates the culture wells triggered by experiment time or BioLector XT microbioreactor online signals. This allows for an increased walk-away time while keeping the same level of quality output. Reproducibility and Scalability
Take advantage of the integrated system to transform your workflow and get reproducible experiment data. The scalable results make it fast and easy to bring more products to market. Software
Incorporating cultivation modes with online triggers (real-time signals from the BioLector XT microbioreactor), you get the benefits of continuous operation 24/7. Reduce Contamination Risk
Fixed Biomek tips are cleaned and decontaminated between actions reducing the potential for cross-contamination. ... Read More | Optimize dependability and walk-away time.
The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry-leading brand - combined with enhancements suggested by customers around the globe. - Ideal for medium- to high-throughput
Optimize dependability and walk-away time.
The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry-leading brand - combined with enhancements suggested by customers around the globe. - Ideal for medium- to high-throughput workflows
- 25 deck positions
- 0.5 µL-1,000 µL (Multichannel) or 0.5 µL-5,000 µL (Span-8) pipetting volume ranges
- Single Multichannel head (96/384) or Span-8 pipetting with gripper
Features of the Biomek i5 Automated Workstation
Versatile Workspace
- Open platform with grid-based deck
- Internal LED light illuminates workspace
- Automated Labware Positioners (ALPs) for sample processing
- Optional enclosed version to protect samples from airborne particles
- Integrate additional devices on- or off-deck
- Configurable for specific applications
Flexible Pipetting & Workflow Management
- Multichannel head (96/384) or Span-8 pipetting
- Large-volume 1 mL multichannel pipetting head
- High-access, rotating gripper with unique offset finger design
- Disposable & fixed Biomek tips, including septum piercing
- Transfer volumes from 0.5 µL - 5,000 µL
- Independent Span-8 probe calibration
- 8 channel liquid-level sensing
- Supports labware from tubes to 1,536-well microplates
- Accurate intra-well pipetting
Simple System Operation
- Easily automate existing processes and execute quick workflow changes
- Powered by icon-based software with data tracking and LIMS connectivity
- Windows 10 OS
- Extend walk-away operation with process management and scheduling software
- Automated deck framing
- Data-driven operations including hit-picking & normalization
- Light curtain safety feature
- Instrument status light bar
- DeckOptix cameras for live, remote-monitoring & on-error video capture
Application-Focused Solutions
- Consultative workflow analysis
- Expert application & technical support
- Biomek automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows
... Read More | The most powerful and comprehensive Biomek available.
- High-throughput
- 45 deck positions
- 0.5 - 5,000 µL pipetting volume range
- Single or dual heads
Biomek i7 Automated Workstation Features
Versatile Workspace
- Spacious, open-platform with grid-based deck
- Up to 45 deck positions
- Internal LED
The most powerful and comprehensive Biomek available.
- High-throughput
- 45 deck positions
- 0.5 - 5,000 µL pipetting volume range
- Single or dual heads
Biomek i7 Automated Workstation Features
Versatile Workspace
- Spacious, open-platform with grid-based deck
- Up to 45 deck positions
- Internal LED light
- Automated Labware Positioners (ALPs) for sample processing
- Optional enclosed version to protect samples from airborne particles
- Integrate additional devices on- or off-deck
- Configurable for specific applications
Flexible Pipetting and Workflow Management
- Multiple single- & dual-arm configurations with Multichannel heads (96/384/Pin tool) and/or Span-8 pipetting
- Large-volume 1 mL multichannel pipetting head
- High-access, rotating gripper(s) with unique offset finger design
- Disposable & fixed Biomek pipette tips (including septum piercing)
- Transfer volumes from 0.5 µL - 5,000 µL
- Independent Span-8 probe calibration
- 8 channel liquid-level sensing
- Supports labware from tubes to 1,536-well microplates
- Accurate intra-well pipetting
Simple System Operation
- Easily automate existing processes & execute quick workflow changes
- Powered by icon-based software with data tracking & LIMS connectivity
- Windows 10 OS
- Extend walk-away operation with process management and scheduling software
- Guided system setup
- Automated deck framing
- Data-driven method operations including hit-picking & normalization
- Light curtain safety feature
- Instrument status light bar
- DeckOptix cameras for live, remote-monitoring & on-error video capture
Application-focused Solutions
- Consultative workflow analysis
- Expert application & technical support
- Biomek-automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows
... Read More | For aqueous-based acoustic transfers
- Designed for biochemical and genomic sample and reagent transfer
- Improve data quality while saving on reagent costs
- Reagent reservoir for larger volume reagent transfers
Echo 525 Liquid Handler Features
Key Benefits
- Highly precise and accurate low volume
For aqueous-based acoustic transfers
- Designed for biochemical and genomic sample and reagent transfer
- Improve data quality while saving on reagent costs
- Reagent reservoir for larger volume reagent transfers
Echo 525 Liquid Handler Features
Key Benefits
- Highly precise and accurate low volume transfers enabling assay miniaturization
- Builds assays 50–100 times faster than traditional liquid handlers giving the lab higher capacity from one instrument
- Suite of Echo Software Applications guide creation of complex protocols for a variety of applications
- Eliminates pipetting variances that affect assay success
- Integrates into the Labcyte Access Laboratory Workstation for increased throughput
Build Complex Assays Quickly
The flexibility, speed, accuracy, and precision of the Echo 525 Liquid Handler enable researchers to build assays that are not possible with traditional liquid handlers. The use of acoustic sound energy removes the traditional boundaries of tip and pin tool based liquid handlers. Transfer variable fluid heights and viscosities from one source plate to enable rapid assay creation in one fluid transfer run. Say goodbye to fixed plate designs as the Echo Liquid Handler moves fluids from any well to any well enabling researchers to design the experimental plates they need to make new discoveries. Efficiently Transfer Build Reagents with Echo Qualified Reservoir
Assay assembly and the transfer of one reagent to many wells is simplified using the Echo Qualified Reservoir. With the capability of transferring up to 2.5 µL from each micro-well, you can build your assay without requiring an instrument change – saving time and money. Flexible and Reliable Transfer of Genomic Reagents
The Echo 525 Liquid Handler transfers a wide range of fluids during one transfer including distilled water, buffers, nucleic acids, and reagents containing up to 50% glycerol. With its versatile fluid range, transfer volume range, any well to any well transfer capability, and powerful applications software the Echo 525 Liquid Handler supports a wide range of genomic assay workflows: - Gene Synthesis
- PCR and qPCR assay set-up
- RNA and DNA NGS sequencing workflows
- Sanger sequencing assay set-up
- Single-cell sample preparation
... Read More |
| Applications | Automated sampling, automated induction, induction profiling, synchronized process manipulation, pH profiling, feeding profiling, media preparation, process characterization, high-throughput protein expression, and automated upstream processing with microbial cultures | Automated sampling/harvesting, automated inoculation of cultivation wells, automated induction, bolus feeding / repeated fed-batch, induction profiling, microbial growth synchronization, feed profiling, media preparation, and automated upstream processing with microbial cultures | Genomic, drug discovery & basic research | Genomic, drug discovery & basic research workflows | Biochemical and genomics reagent transfer |