| Description | RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system autonomously prepares media compositions, among others, from the design of experiments (DoE) tests, followed by an online-monitored high-throughput cultivation.
Furthermore, pH adjustments can be made and inducers as well as feed solutions can be added to each cultivation well according to a pre-defined schedule or triggered by online process signals. Automated sampling into various targets including a cooling station facilitates optimal process monitoring and control.
Features of the RoboLector XL
Cultivation Modes - DO or time controlled feeding
- Fed-batch with bolus feeding
- Repeated fed-batch
- Biomass dependent sampling or dosing
- Time dependent sampling or dosing
- pH adjustments
Online Trigger Signals - Biomass concentration
- pH, DO (using optodes)
- Fluorescent molecules (GFP, YFP, DsRed ...)
- NAD(P)H and riboflavins
- Process or induction time
- Working volume
Advantages - Automated upstream processing of up to 48 parallel cultivations
- Continuous operation 24 hours/day and 7 days/week
- Plug & Play disposable technology
- Design of experiments (DoE)• Detailed process understanding in short time
- Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
- Reliable scale-up to lab-fermenters
- Fast and easy data analysis
- A valuable tool for PAT and QbD
- Processing units possible (for custom made solutions)
Applications - Automated sampling
- Automated induction
- Induction profiling
- Synchronized process manipulation
- pH profiling
- Feeding profiling
- Media preparation
- Process characterization
- High-throughput protein expression
- Automated upstream processing with microbial cultures
... Read More | The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter technologies into one advanced platform that empowers lab managers with a far more effective, high-throughput method—offering increased confidence that promising clones don’t get overlooked in the process of The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter technologies into one advanced platform that empowers lab managers with a far more effective, high-throughput method—offering increased confidence that promising clones don’t get overlooked in the process of consistently selecting the best.
- High-throughput clone screening in cell line development
- Automated, walk-away operation
- All results in one software
- pH-controlled fed-batch cultivation of 96 parallel clones with individual gassing
- On-deck cell count, viability and antibody titer analysis
- Fully integrated system
... Read More | The OptiMATE Gradient Maker automates the preparation of density gradients for ultracentrifugation. Density gradient ultracentrifugation is a gradient-based purification system that provides precise purification of samples based on their differences in particle loading or densities. This system:
The OptiMATE Gradient Maker automates the preparation of density gradients for ultracentrifugation. Density gradient ultracentrifugation is a gradient-based purification system that provides precise purification of samples based on their differences in particle loading or densities. This system:
- Provides a software interface for creating a density gradient profile and layering samples
- Optimizes density gradient dispensing to reduce centrifugation time
- Automatically and rapidly dispenses a precise density gradient tube
- Automates the sealing of Beckman Coulter Quick-Seal centrifuge tubes
... Read More | PAT700 TOC Analyzer Overview
PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection. - TOC, Uncompensated Conductivity and Temperature from just one
PAT700 TOC Analyzer Overview
PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to help demonstrate compliance to the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection. - TOC, Uncompensated Conductivity and Temperature from just one analyzer – can be fully calibrated and validated to USP<643> and USP<645>
- Low cost of ownership – 12 month service and calibration intervals
- Root-cause analysis support – water sample automatically taken if there is a TOC excursion
- All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
PAT700 TOC Analyzer Features
Low cost of ownership
- 12 month service intervals supported by auto-switching Main and Standby UV oxidation lamps with UV output monitoring
- No chemicals/reagents required – PAT700 just uses strong UV lamps to oxidize TOC
- No peristaltic pump tubing or pump heads to replace – PAT700 uses water system pressure to push sample into measurement cell for analysis
Root-cause analysis support
- User can pre-program the PAT700 so that at a pre-determined TOC level, it will capture a water sample which can then be later analyzed in the QC Lab to assist root cause analysis should a TOC excursion be detected
- On-board grab sampler allows the user to take samples from different locations/use points to support root cause analysis
Improved compliance
- PAT700 can be fully calibrated and validated for compliance to USP<643> for TOC and USP<645> for conductivity
- Complete oxidation to EP 2.2.44 requirements – the PAT700 ensures complete TOC oxidation through oxidation dynamic end-point detection
- 21CFR part 11 support – everyday users can view TOC and Conductivity results as a Guest without the ability to make any changes to the PAT700. Initial configuration and subsequent changes are protected through multi-level user name and password protection
- Dual-stream version available to demonstrate compliance both at the start and end of water loops simultaneously
Reduced training burden – no manual calculations/data entry
- All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
- All Calibration and System Suitability standards come with certified value data and use by dates programmed into an RFID tag on the bottle itself. Following the on-screen SOPs the user is prompted to load the bottles and the PAT700 then reads the RFID tags on the bottles. If the bottles have been loaded in the wrong order, or if they have expired the PAT700 provides a warning on the touch-screen. The PAT700 then uploads certified values, carries out the test and automatically calculates a pass/fail result and provides a report.
... Read More | Proven Performance and Reliability
The TQ-Prep Workstation delivers whole blood lysis cell preparations for your flow cytometry needs time after time. A standard 32-tube carousel allows walk-away processing and perfectly complements our Navios EX flow cytometer. The IMMUNOPREP Reagent System with Proven Performance and Reliability
The TQ-Prep Workstation delivers whole blood lysis cell preparations for your flow cytometry needs time after time. A standard 32-tube carousel allows walk-away processing and perfectly complements our Navios EX flow cytometer. The IMMUNOPREP Reagent System with ready-to-use CYTO-STAT tetraCHROME Monoclonal Antibody Reagents provides fast no-wash sample preparations for flow cytometric analysis, while maintaining cellular integrity and morphology. - True walkaway operation from onboard incubation and lysis cycle processing
- User-friendly interface with a larger icon-driven touchscreen
- Maximum reliability with minimal maintenance
- The vortex system mixing ensures reproducible homogenous cell lysis
- Reagent dispensing with syringe pump system consistently provides precise and accurate volumes
- Sample throughput of up to 32 samples in only 24 minutes
- Windows 10 IOT (Internet of things) Enterprise LTSC Operating System
- Data transfer via USB
Features
The TQ-Prep Workstation and IMMUNOPREP Reagent System together provide rapid, no-wash whole-blood sample preparation. Automation provides inter-sample and inter-laboratory consistency and reproducibility. Workflow
- Reduced number of repeat samples for cost & labor efficiencies
- Sample throughput of up to 32 samples in 24 minutes
Reliability
- Maximum reliability with minimal maintenance
- Continuous real-time feedback allowing operators to follow incubation & lysing processes
Performance
- Onboard incubation and lysis cycle processing for walkaway operation
- Advanced syringe pump system for precise & accurate reagent dispensing
TQ-Prep Upgraded
- Updated covers for front panel and reagent cover with improved fit
- Data privacy and security enhancements
- Updated safety certificates
- The touch screen interface has been replaced with a capacitive touch display interface
- Display icons have been resized for larger display
... Read More |
| Applications | Automated sampling, automated induction, induction profiling, synchronized process manipulation, pH profiling, feeding profiling, media preparation, process characterization, high-throughput protein expression, and automated upstream processing with microbial cultures | Top clone screening in Cell Line Development | Density Gradient Centrifugation Sample Preparation | Demonstrate compliance with the pharmacopoeial requirements for TOC and conductivity for Purified Water and Water For Injection | Automated no-wash whole-blood sample preparation |