Application Scientist
JASCO
Dr. Kohl is currently an Application Scientist at JASCO specializing in electronic spectroscopy such as circular dichroism. As a PhD, he spearheaded a new direction of research in his lab focused on studying melanin, a heterogeneous carbonaceous material.
He has characterized materials via AFM and SEM as well as hybridized electrochemical-spectrscopic methods. He also studied DNA bound to silver ions using transient measurements as well as CD spectroscopy.
He has experience teaching and mentoring undergraduate students in lab and in the classroom.
The biopharmaceutical market has been expanding dramatically over the past decade, particularly for therapeutic antibodies. As innovative antibodies are developed there is a strong push to develop biosimilars with identical higher order structure (HOS). The HOS of biopharmaceuticals directly impacts their efficacy and safety, which means verifying HOS is of great importance. Current FDA guidelines emphasize the use of orthogonal quantitative methods in the comparison of reference products with biosimilars. For proteins, such as antibodies, circular dichroism, Fourier transform Infrared, and Raman spectroscopy are excellent tools for structural determination. To quantitate spectral difference for these spectroscopic techniques, Jasco has developed qHOS, a powerful spectral assessment tool. In this webinar we outline the study of monoclonal antibody structure using qHOS and various spectroscopic techniques. Learn More Here.
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