Ultra High Performance Liquid Chromatograph (UHPLC)

Ultra high-performance liquid chromatography, UHPLC, uses columns packed with porous sub-2-µm particles (usually 1.8 µm) to vastly increase throughput and resolving power compared to conventional 5-µm columns. Pressures can surpass 19,000 psi. Limited solvent consumption, the ability to work under a broader pressure range, and lower band broadening are further enhancements. UHPLC’s 10× reduction in analysis time strengthens its popularity in areas including the pharmaceutical industry, food safety, and the clinical field. The choice of detectors for use with UHPLC is wide-ranging, including UV-VIS, fluorescence, photodiode array, ELSD, quadrupole, and most recently, refractive index. For flexibility, many instruments offer the ability to run both conventional and UHPLC on one instrument. A final tip: When making the switch from HPLC to UHPLC, resist the temptation to overload the smaller columns.

Discover and compare Ultra High Performance Liquid Chromatographs:

CompanyShimadzuShimadzuShimadzuShimadzuShimadzu
ItemNexera XR UHPLC SystemCBM-40 HPLC/UHPLC System ControllerNexera UCs UHPLC/SFC Switcing SystemNexera XS UHPLC SystemNexera-i MT Method Transfer System
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Catalog NumberNexera XRCBM-40Nexera UC SwitchingNexera XSNexera-I MT
Price
DescriptionNexera XR is perfect for fast separations using the popular SPP column phases for high efficiency and lower back pressure. This system offers a rugged and forgiving UHPLC workflow, with five to ten-minute separations. With Analytical Intelligence functions, the system makes lab management simple, ... Read MoreThe CBM-40 is a small-profile unit that stacks neatly with main system components. Other LC modules connect via fiber optic cables for easy "plug and play" system configuration. An internal web server offers convenient control and monitoring of the UHPLC system through a web browser, LabSolutions ... Read MoreThis system can switch automatically between SFC analysis and UHPLC analysis and make measurements on a single sample in each separation mode. It enhances user-friendliness and efficiency by allowing the investigation of separation conditions and performing reverse-phase high-speed analysis in a ... Read MoreThe Nexera XS UHPLC excels at fast separations, easily handling small ID UHPLC columns with sub-2 micron particles or the popular SPP phases for high efficiency and lower back pressure. A common XS configuration may have a 4-channel solvent selection valve on each pump providing versatility for ... Read MoreEnables Both HPLC and UHPLC Analysis

The Nexera-i MT is a new addition to the i-Series lineup. It enables both conventional analysis via its high compatibility with existing LC systems and rapid analysis via high-speed methods. In pharmaceutical development, a single integrated system allows
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QuantityEAEAEAEAEA
Detector(s)UV, PDA, ELSD, Fluorescence, RID, ConductivityInquireInquireUV, PDA, ELSD, Fluorescence, RID, ConductivityInquire
Flow Rate0.0001 – 3 mL/min (1.0 – 70 MPa); 3 – 5 mL/min (1.0 – 44 MPa); 5 – 10 mL/min (1.0 – 22 MPa)InquireInquire0.0001 – 3 mL/min (1.0 – 105 MPa); 3 – 5 mL/min (1.0 – 80 MPa); 5 – 10 mL/min (1.0 – 22 MPa)Inquire
Max. Pressure70 MpaInquireInquire105 MpaInquire
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