High performance liquid chromatography (HPLC) is a well-known, tried and trusted method for mixture separation, widely used for quality analysis and control, as well as laboratory sample preparation. Preparative HPLC systems (including semi preparative and narrow-bore) accomplish high flow rates of up to 100ml/min and at pressures of up to 50 bar/725psi, with high volumetric linearity. A preparative HPLC system typically employs a UV, RID and/or IR detector for highly accurate separation analysis. When looking to purchase a preparative HPLC system, one must pay note to models that provide interoperability with other lab equipment, real time computer analysis and control (or computer-independent control) and comprehensive database storage options.
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | Nexera Ultra Fast Preparative Liquid Chromatography | Nexera Preparative HPLC System | Nexera UC Prep |
| Catalog Number | Nexera UFPLC | Nexera Prep HPLC | |
| Price | | | |
| Detector(s) | UV, PDA, ELSD, LCMS, or any A/D compatible detector | LCMS, RID, ELSD | UV/VIS detector (SPD-40, SPD-40V; 190–700 nm / 190–1000 nm); Photodiode array detector (SPD-M40; 190–800 nm) |
| Flow Rate | up to 150 mL/min | up to 150 mL/min | 10.0 to 150.0 mL/min (Stacked/Multi-Fraction prep systems); 0.0001 to 5.0 mL/min (Analytical Fraction System) |
| Max. Pressure | 42 MPa | Inquire | 44 MPa (CO2 delivery pump, up to 100 mL/min); 33 MPa (up to 150 mL/min); back pressure regulator: 1–40 MPa |
| Description | The Nexera UFPLC ultrafast preparative and purification LC streamlines purification operations by automating the preparative process from separation to concentration, purification, and collection. Nexera UFPLC concentrates target components by using a trap column. In addition, salts derived from theThe Nexera UFPLC ultrafast preparative and purification LC streamlines purification operations by automating the preparative process from separation to concentration, purification, and collection. Nexera UFPLC concentrates target components by using a trap column. In addition, salts derived from the mobile phase and counter ions of the target compound are removed. Furthermore, because organic solvents are used to elute the target components, the time for evaporation can be significantly reduced.
Key features include:
- Automatic Removal of Non-volatile Salts and Counter Ions - In conventional preparative LC, salts derived from the mobile phase are included in the recovered product. With Nexera UFPLC, salts derived from the mobile phase can be removed on the trap column.
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Concentration and Powdering of Target Ingredients in a Short Period of Time - Samples are repeatedly injected, and the target components are introduced into the same trap column, allowing concentration on the trap column (up to 100 mg capacity). After concentration, the target component is eluted with an organic solvent, allowing recovery of the target component at a high concentration and shortening the time for evaporation.
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Easy to Operate Dedicated Software - Dedicated Purification Solution software simplifies settings related to preparative purification and is equipped with peak tracking functions that allow confirming the analysis status at a glance. Three fractionation modes: automated, manual, and time-specified fractionation mode, ensure valuable samples are fractionated.
Nexera UFPLC can also be used for standard preparative chromatography by collecting the fractions directly without any concentration steps.... Read More | The Nexera Prep products represent complete solutions for preparative purification chromatography resulting in clean, repeatable isolates and with a workflow friendly to lab personnel of all experience levels.
Nexera Prep offers flexible hardware options to cover your purification needs. The The Nexera Prep products represent complete solutions for preparative purification chromatography resulting in clean, repeatable isolates and with a workflow friendly to lab personnel of all experience levels.
Nexera Prep offers flexible hardware options to cover your purification needs. The software workflow makes it easy to translate an analytical run into dependable preparative-scale peak fraction collections; changes to method and collection parameters can be made on the fly.... Read More | Inquire |
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