A gel permeation chromatograph (GPC) is used to separate the components of a sample by size, this is known as size-exclusion chromatography (SEC).
GPC systems are widely used to analyze polymers and proteins in manufacturing, chemistry, and biology labs for quality control and analysis. GPC systems are composed of porous beads (the gel) inside a column, a pump to move the sample and eluent through the column, and a detector to detect when different analytes are eluted through the column. The detectors can be concentration sensitive or molecular weight sensitive.
Each gel permeation system has a range of sizes it can detect based on the pore sizes of the beads in the column, so before deciding on a system make sure you know the parameters you need. There are different types of porous beads that have varying affinities for materials and it is best for the gel to have a low affinity for the material you wish to analyze.
Discover and compare Gel Permeation Chromatography Systems:
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| Company | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | ACQUITY Advanced Polymer Chromatography (APC) System | Arc HPLC System (GPC/SEC Configuration) |
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| Type | Advanced Polymer Chromatography (APC) / GPC / SEC | HPLC / GPC / SEC |
| Detector(s) | Refractive Index (RI), Ultraviolet (UV), Photodiode Array (PDA), Light Scattering (LS), Viscometry (IV) | TUV, PDA, FLR, RI, ELS, EC |
| Flow Rate | 0.010 to 2.20 mL/min | 0.001 to 5.000 mL/min |
| Column Temp. Range | 4.0 °C to 90.0 °C | 4 to 90 °C |
| Description | Advanced Polymer Chromatography system achieving highest resolution size-based separations 5-20x faster than traditional GPC/SEC | Routine HPLC system with GPC/SEC capability, featuring excellent flow precision (<0.075% RSD) for reliable molecular weight determination |
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