Total Organic Carbon Analyzer (TOC Analyzers)

A total organic carbon analyzer (also referred to as TOC analyzers) measures the amount of total organic carbon present in a liquid or water sample. TOC detection is important because of the effects that TOCs may have on health, not to mention the environmental effects and implications for the pharmaceutical manufacturing processes. Since all total organic carbon analyzers only measure total carbon, a TOC analyzer always requires some accounting for the inorganic carbon (IC) that is always present. TOC analyzers, including a portable TOC analyzer, utilize the same basic technique where acid is added to the liquid sample to remove IC. At this point, the IC is converted into carbon dioxide gas. It is then stripped out of the liquid by a carrier gas where the remaining inorganic carbon-free sample is then oxidized and the carbon dioxide generated from the oxidation process is directly related to the TOC total organic carbon in the sample. There are several methods for introducing the sample to TOC analyzers, including using a syringe, autosampler, and loop sampling. An important specification for total organic carbon analyzers is the measuring range. Carrier gas flow rate, average analysis time and process temperature are important as well for total organic carbon analysis.

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CompanyAnalytik JenaAnalytik JenaAnalytik JenaAnalytik JenaAnalytik Jena
Itemmulti N/C® Series TOC/TNb Analyzersmulti N/C 2300multi N/C 3300multi N/C 4300 UVmulti N/C pharma
Citations
(758)
Catalog Numbermulti N/C 3x00
Price
Measurement Mode(s)TC, TIC, TOC, NPOC, POC, and TNbTC, TIC, TOC, DOC, NPOC, NPOCplus; optional TNb (CLD or ChD)TC, TIC, TOC, DOC, NPOC, NPOCplus; optional TNb (CLD or ChD); optional POC (particulate organic carbon)TC, TIC, TOC, DOC, NPOC, NPOCplus; optional solids TC/TOC/TIC (no TNb)TOC, NPOC, TC, TIC; optional TNb (chemiluminescence, CLD) for combustion models; multi N/C 2100S pharma: TN only for total protein determination
Oxidation MethodHigh temperature combustion / Wet chemical oxidation by UV radiation (254 nm+185 nm) /persulfate dependent on instrument configurationCatalytic high-temperature combustion up to 950°C; optional catalyst-free oxidation up to 1300°C (solids with HT 1300 module)Catalytic high-temperature combustion up to 950°C (liquids); catalyst-free oxidation up to 1300°C (solids, duo models)UV wet chemical digestion (high-power UV reactor, 254 nm and 185 nm wavelengths); optional non-catalytic high-temperature combustion up to 1300°C for solids (HT 1300 module)pharma UV: UV wet chemical digestion (254 nm + 185 nm, High Power Long Life UV reactor); pharma HT and 3100 pharma: thermocatalytic high-temperature combustion up to 950°C
Measuring Range0–30,000 mg/L C0–30,000 mg/L C; TNb: 0–200 mg/L (CLD) or 0–100 mg/L (ChD)0–30,000 mg/L C; TNb: 0–200 mg/L (CLD) or 0–100 mg/L (ChD); Solids: 0–100 wt-%0–10,000 mg/L Cpharma UV: 1 µg/L – 10,000 mg/L C; 3100 pharma: 4 µg/L – 30,000 mg/L C; 2100S pharma: 5 µg/L – 200 mg/L TN
Detection Limit1 µg/L C - 50 µg/L C dependent on instrument configuration50 µg/L C; TNb (CLD): 5 µg/L; TNb (ChD): 50 µg/L4 µg/L C; TNb (CLD): 5 µg/L; TNb (ChD): 50 µg/L1 µg/L Cpharma UV: 1 µg/L C (ultra-trace without persulfate); pharma HT: 4 µg/L C; 3100 pharma: 4 µg/L C; 2100S pharma: 5 µg/L TN
Sample Volume50–20,000 µL variable dependent on instrument configuration10–500 µL (direct injection by microliter syringe)50–1000 µL (standard); 50–3000 µL (3300 HS model)50–20,000 µL (flow injection)pharma UV: up to 20 mL (flow injection); pharma HT: up to 3 mL (flow injection); 3100 pharma: up to 1 mL (ceramic valve, flow injection); 2100S pharma: 50–500 µL (direct syringe injection)
Measurement AccuracyInquireRSD 2–3%RSD 1–2%1–2%Inquire
Measuring TimeApprox. 3–5 min for each parameter3–5 min/sample3–5 min/sample3–5 min/sampleInquire
Descriptionmulti N/C Series Robust and reliable for any TOC/TNb application
  • Reliable analysis of TC, TIC, TOC, NPOC, POC, and TNb
  • Guaranteed compliance with standards (e.g. DIN 1484, 15936, 12260...)
  • Accurate results even with complicated matrices
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