Multi Angle Light Scattering (MALS) detectors are benchtop systems for characterization and quantification of proteins, peptides, macromolecules, and polymers. A MALS detector is a type of light scattering measurement system, which allows for the detection of light scattered by components of a solution into multiple distinct angles. Many times MALS detectors are coupled with a separation system, such as FFF or SEC.
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| Company | Waters | Wyatt Technology |
| Item | DAWN™ Multi-angle Light Scattering (MALS) Instrument |
| Reviews | |
| Catalog Number | DAWN |
| Price | |
| Description | The DAWN™ instrument is an advanced detector for precise characterization of proteins, polymers, and nanoparticles including viral vectors, lipid nanoparticles and vesicles. Using multi-angle static light scattering (MALS) and optional dynamic light scattering (DLS), DAWN analyzes molar massThe DAWN™ instrument is an advanced detector for precise characterization of proteins, polymers, and nanoparticles including viral vectors, lipid nanoparticles and vesicles. Using multi-angle static light scattering (MALS) and optional dynamic light scattering (DLS), DAWN analyzes molar mass, size, conformation, particle concentration, conjugation (e.g. glycoproteins) or encapsulation (e.g. AAV capsid content). It stands out with exceptional sensitivity and the widest range of molecular weight, size, and concentration of any MALS instrument, paired with a broad selection of configurations and optional modules for enhanced capabilities.
The DAWN is most often used in conjunction with gel permeation chromatography (GPC-MALS), size exclusion chromatography (SEC-MALS) or an EclipseTM, field-flow fractionation instrument (FFF-MALS) and may also be used with ion-exchange chromatography or reverse-phase chromatography. The instrument includes a high-resolution, touch-screen front panel to display data graphs, system health and instrument diagnostics and is accompanied by ASTRA™, the most versatile software package available for analysis of online multi-angle and dynamic light scattering.... Read More |
| Type | MALS and optional DLS |
| Measuring Range | 200 Da to 1000 MDa |
| Detector(s) | High-gain, high-dynamic-range photodiodes at 18 angles for MALS; optional avalanche photodiode that may be placed at any of four angles for DLS.
Fluorescence-blocking filters available for use with analytes that fluoresce when illuminated at the MALS wavelength. |
| Light Source | 658 nm laser, programmable 10% - 100% of maximum power.
Optional: 785 nm for fluorescence suppression |
| Wavelength(s) | 658 nm; 785 nm available for fluorescence reduction (with lower sensitivity than 658 nm) |
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