Particle Counting (Particle Counter)

We provide scalable Facility Monitoring Systems (FMS) that can be configured to meet a wide spectrum of cleanroom management needs for various industries—including pharmaceutical production. Among parameters that can be efficiently and reliably

We provide scalable Facility Monitoring Systems (FMS) that can be configured to meet a wide spectrum of cleanroom management needs for various industries—including pharmaceutical production. Among parameters that can be efficiently and reliably monitored using a Beckman Coulter FMS are non-viable/viable air sampling, differential pressure, air temperature and relative humidity. All of the company’s FMS solutions are based on an open-architecture platform designed to enable easy, streamlined integration with existing customer systems (SCADA). Each instrument is built around proven MET ONE technology, including the portable MET ONE 3400 series for routine monitoring and cleanroom classification, as well as the 6000 and 7000 series of fixed, non-viable air particle counters. MET ONE software platforms feature intuitive interfaces to help make them easy to use, thereby reducing the potential for human error that can occur with manual SOP monitoring. To avoid losses from product contamination, stack lights, audible alarms and process shutdown signals from a Beckman Coulter FMS can prompt an immediate production line response whenever an excursion happens. In addition, to help centralize reporting and simplify EUGMP/FDA compliance (e.g., for ISO 14644 and 21 CFR Part 11), Beckman FMS data can be integrated into a single-release, electronically signed paperless report.

• Workflow-optimized, integrated solutions to monitor your cleanroom
• 21 CFR Part 11 enabling software workflow to ensure secure data management
• Integrate portables and remote air particle counters
• Industry standard interfaces (OPC, ODBC) for integration with other systems
• Support for 32 location manifold integration for automated routine environmental monitoring

• Nonviable and viable particle monitoring compliant with EU GMP
• Annex 1 and FDA 21 CFR Part 11
• Built in Audit Logging
• Custom reports to record results
• IQ/OQ documentation for simple validation

• Small scale, rapidly deployed pre-packaged software and hardware for isolators and small production line
• Batch workflow system for one or more production lines with several monitoring points
• Custom workflow optimized solutions for monitoring complex production methods across several production lines

• Regional Service Professionals provide onsite ISO 21501-4 calibration and service
• Service agreement options for pre-scheduled onsite calibration and maintenance (including discounts for repairs)

• Graphical user interfaces available on the system or via remote access terminals
• Color coded indication of system status
• Alarms clearly identified for acknowledgement
• Single click reports to generate auditable records for compliance

MET ONE HHPC+ Series handheld particle counters allow easy ISO Class 5 to 7 monitoring in hard-to-reach places. Lightweight with a high-resolution display, these handheld counters are ideal for routine monitoring of controlled environments and

MET ONE HHPC+ Series handheld particle counters allow easy ISO Class 5 to 7 monitoring in hard-to-reach places. Lightweight with a high-resolution display, these handheld counters are ideal for routine monitoring of controlled environments and mini-environments, easy filter leak troubleshooting for particle-contamination issues, spot-checking critical areas, and targeting particle generation within process equipment.

• ISO 14644-1 industry standard
• CFR 21 Part 11 compliance enabled
• 0.3 μm - 10.0 μm particle detection
• 2-6 channel detection
• Single-hand operation
• PC access to particle counting data via Ethernet, USB, or cable for data transfer options

• ISO 14644-1 Class 5 (FED STD Class 100 or higher) compliant sampling
• Counting efficiency to ISO 21501-4
• Zero count level to JIS B9921

• On-the-spot process profiling for fast particle event tracking
• Easy network connectivity for 21 CFR Part 11 compliance
• Store up to 10,000 records
• Convenient charge cradle for access to particle counting data via Ethernet or USB cable
• Data download via Ethernet
• Connectivity through USB and memory card

• Easy-to-read high resolution display
• Fully configurable display
• Slim & lightweight design (0.7 kg) for single-hand use

• Routine monitoring in high-tech manufacturing & GMP-regulated cleanrooms
• Particle contamination troubleshooting in critical processing areas
• Spot checking & troubleshooting in mini-environments & workstations

• MET ONE R4800 series remote air particle counters use standard RS-485 serial communications
• MET ONE R4900 series remote air particle counters use industry standard 4-20mA interface
• Stainless steel enclosure compatible with most process environments
• Compact size for easy mounting with a vacuum source, DC power & communication line

• MET ONE R4800 & R4900 counters respond to simple ASCII command instructions, including start, stop and report counts, send location number, etc.
• Reporting data includes counter status & particle counts in two size ranges
• Multiple display options via continuous monitoring feature (Particle Vision® Online & CIMScan® software

• User-programmed alarm level detects high counts on first channel triggering an alarm
• Auto alarm reset at start of the next count cycle
• Long-life laser technology for superior performance & extended service life
• No fan allows proximate placement to sensitive processing areas

• Sensitivity ranges of 0.5um & flow rates of 1.0 cfm
• Onboard status indicator sets signal at connector for alarm Stay resident RS-485 configuration programming (count/hold times, alarm level/delay & scaling) maintained through power cycles
• Sensor resistant to vaporous hydrogen peroxide (VHP)

The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 - 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-

The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 - 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

Generated data are processed using patented digital pulse processing technology and can be saved and later re-analyzed. This technology provides ultra high resolution and accuracy unattainable through any other technologies: detection of 1 particle in 1 ml of a sample with the optimal instrument configuration. Analysis results are not dependent on particle shape, structure, or optical properties.

It uses the Coulter principle to detect particles via electrical zone sensing, regardless of the particle’s nature or optical properties. This makes it an ideal tool for detecting and counting a wide variety of particles, such as:

• Mammalian cells
• Bacteria
• Yeast
• Abrasives
• Toner particles
• Cell aggregates
• Spheroids
• Large protein aggregates

• Aperture sizes from 10 µm - 2000 µm in diameter for current & future needs
• Multiple aperture options & data overlay capability for analyzing complex samples over wide particle size distribution

• Analyze materials in aqueous or non-aqueous solvents
• Ideal for biological or non-biological samples
• Detect particles regardless of material type or optical properties

• Typical sampling rates up to 10,000 counts per second
• Detect & count particles from 0.2 µm - 1600 µm in diameter
• Sample volumes as small as 5 mL

• Digital pulse data can be stored & re-analyzed as needed
• CFR 21 Part 11 compliant software for audit control & security
• Variety of calibration beads & V-check validation controls