Particle Counting (Particle Counter)

The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 - 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-

The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 - 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

Generated data are processed using patented digital pulse processing technology and can be saved and later re-analyzed. This technology provides ultra high resolution and accuracy unattainable through any other technologies: detection of 1 particle in 1 ml of a sample with the optimal instrument configuration. Analysis results are not dependent on particle shape, structure, or optical properties.

It uses the Coulter principle to detect particles via electrical zone sensing, regardless of the particle’s nature or optical properties. This makes it an ideal tool for detecting and counting a wide variety of particles, such as:

• Mammalian cells
• Bacteria
• Yeast
• Abrasives
• Toner particles
• Cell aggregates
• Spheroids
• Large protein aggregates

• Aperture sizes from 10 µm - 2000 µm in diameter for current & future needs
• Multiple aperture options & data overlay capability for analyzing complex samples over wide particle size distribution

• Analyze materials in aqueous or non-aqueous solvents
• Ideal for biological or non-biological samples
• Detect particles regardless of material type or optical properties

• Typical sampling rates up to 10,000 counts per second
• Detect & count particles from 0.2 µm - 1600 µm in diameter
• Sample volumes as small as 5 mL

• Digital pulse data can be stored & re-analyzed as needed
• CFR 21 Part 11 compliant software for audit control & security
• Variety of calibration beads & V-check validation controls

MET ONE 6000 air particle counters are a compact design with flexible sizing, flow rate and communication options that address the specific needs of cleanroom environments within the pharmaceutical, semiconductor, hard disk drive and flat panel

MET ONE 6000 air particle counters are a compact design with flexible sizing, flow rate and communication options that address the specific needs of cleanroom environments within the pharmaceutical, semiconductor, hard disk drive and flat panel display industries providing ISO 21501 accuracy for continuous particle monitoring. Reduce initial installation cost with MET ONE 6000 remote air particle counter’s integrated multi-parameter measurements.

• Industry leading particle counting on-line reliability
• Flexible for all your remote air particle counter applications
• Flexible particle count size in 0.3µm or 0.5µm; 0.1cfm or 1.0cfm flow rates
• Long life laser diode for guaranteed continuous monitoring.
• Easy to integrate with any facility monitoring system
• Open architecture design to communicate seamlessly with your system
• Count alarm and alerts enable visual notification via built-in status lights.
• Optional relative humidity and temperature probe integrates RH/T data with particle count data in same data stream.
• In compliance with ISO 14644, FDA CGMP and EU GMP Annex 1

• ISO21501 compliance ensures accuracy and instrument to instrument repeatability
• Data security to enable 21 CFR Part 11 compliance

• The MET ONE 6000 remote air particle counter is specifically designed to manage all aseptic fill clean room fixed location applications
• Enables compliance with 21 CFR Part 11, FDA cGMP, and EU GMP Annex 1

• Industry’s most accurate particle counting fully complies to ISO21501 calibration standards and assures increased yield

• Increase yield and eliminate contamination concerns in flat panel production
• Low cost of ownership price-per-point particle counting with industry leading high quality

We provide scalable Facility Monitoring Systems (FMS) that can be configured to meet a wide spectrum of cleanroom management needs for various industries—including pharmaceutical production. Among parameters that can be efficiently and reliably

We provide scalable Facility Monitoring Systems (FMS) that can be configured to meet a wide spectrum of cleanroom management needs for various industries—including pharmaceutical production. Among parameters that can be efficiently and reliably monitored using a Beckman Coulter FMS are non-viable/viable air sampling, differential pressure, air temperature and relative humidity. All of the company’s FMS solutions are based on an open-architecture platform designed to enable easy, streamlined integration with existing customer systems (SCADA). Each instrument is built around proven MET ONE technology, including the portable MET ONE 3400 series for routine monitoring and cleanroom classification, as well as the 6000 and 7000 series of fixed, non-viable air particle counters. MET ONE software platforms feature intuitive interfaces to help make them easy to use, thereby reducing the potential for human error that can occur with manual SOP monitoring. To avoid losses from product contamination, stack lights, audible alarms and process shutdown signals from a Beckman Coulter FMS can prompt an immediate production line response whenever an excursion happens. In addition, to help centralize reporting and simplify EUGMP/FDA compliance (e.g., for ISO 14644 and 21 CFR Part 11), Beckman FMS data can be integrated into a single-release, electronically signed paperless report.

• Workflow-optimized, integrated solutions to monitor your cleanroom
• 21 CFR Part 11 enabling software workflow to ensure secure data management
• Integrate portables and remote air particle counters
• Industry standard interfaces (OPC, ODBC) for integration with other systems
• Support for 32 location manifold integration for automated routine environmental monitoring

• Nonviable and viable particle monitoring compliant with EU GMP
• Annex 1 and FDA 21 CFR Part 11
• Built in Audit Logging
• Custom reports to record results
• IQ/OQ documentation for simple validation

• Small scale, rapidly deployed pre-packaged software and hardware for isolators and small production line
• Batch workflow system for one or more production lines with several monitoring points
• Custom workflow optimized solutions for monitoring complex production methods across several production lines

• Regional Service Professionals provide onsite ISO 21501-4 calibration and service
• Service agreement options for pre-scheduled onsite calibration and maintenance (including discounts for repairs)

• Graphical user interfaces available on the system or via remote access terminals
• Color coded indication of system status
• Alarms clearly identified for acknowledgement
• Single click reports to generate auditable records for compliance