|  |  |  |
| Company | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | DynaPro Plate Reader 4 Dynamic Light Scattering Instrument | Aura CL System Particle Analyzers | microDAWN™ Multi-Angle Light Scattering Instrument for UHP-SEC-MALS |
| Citations | | | |
| Catalog Number | DynaPro Plate Reader 4 | Aura CL | microDAWN |
| Price | | | |
| Description | The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply load and walk away. Measurements are completed in standard 96, 384 or 1536 disposable well plates and the instrument can be integrated with plate and liquid-handling robots for additional time savings.... Read More | Accurately identify, count, and characterize subvisible particle contaminants in minutes with Aura CL
Measuring particles in cell therapy manufacturing has always been a challenge, and the fact that the drug product itself is a particle makes it even harder.
Waters Aura CL System is the first Accurately identify, count, and characterize subvisible particle contaminants in minutes with Aura CL
Measuring particles in cell therapy manufacturing has always been a challenge, and the fact that the drug product itself is a particle makes it even harder.
Waters Aura CL System is the first system that, unlike traditional methods, quickly identifies and distinguishes cells from protein aggregates or harm-causing particles while providing all required cytometric capabilities—counting cells, identifying types, and measuring viability in one simple assay.
Powered by innovative technology, Waters Aura CL System is the ultimate tool to identify, count, and characterize subvisible particle contaminants introduced in cell therapy manufacturing—so you can access high-throughput insights earlier in discovery to develop cell therapies faster, smarter, and safer.
Features:- Detect and count residual Dynabeads. Finding and counting Dynabeads™* is easier than ever with Aura CL System. Unlike traditional methods that can be subjective, cumbersome, inaccurate, and prone to error, this powerful, fully automated tool allows you to make an accurate count at high speed.
-
ID cells/non cells. Rather than spending hours manually sorting through images or learning how to use complex machine learning libraries, Aura CL System makes it easy to precisely ID cells from non-cell aggregates right out of the box.
-
Analyze small volumes. Analyze small volumes. You only need 5 µL of sample, which allows for particle and cell characterization earlier in development.
-
Learn more with innovative technology. Using backgrounded membrane imaging (BMI) and fluorescence membrane microscopy (FMM), Aura CL System performs cell viability assays with definitive cell identification for 96 40-µL samples in under an hour.
... Read More | The microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size andThe microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and concentrations. In most respects, the microDAWN is similar to the well-established miniDAWN, a workhorse MALS instrument used in hundreds of labs around the world for characterizing proteins and other molecules smaller than 50 nm in radius. The microDAWN is uniquely suitable for use in conjunction with UHPLC Size Exclusion Chromatography (µSEC-MALS) thanks to its small interdetector dispersion and produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC. In some cases it may be used with ion-exchange or other types of chromatography.... Read More |
| Type | Dynamic Light Scattering / Static Light Scattering | Inquire | MALS and optional DLS |
| Particle Size | 0.5 to 1000 nm | Range from >1 µm (ECD) to <5 mm (ECD) | Inquire |
| Detector(s) | Linearized avalanche photodiode for dynamic and static light scattering | Inquire | High-gain, high dynamic range, static light scattering detectors at 3 angles |
| Measuring Time | Measurement Time: 5 to 60 seconds per well
830 nm | 1 minute/sample (BMI read time). 3 FL channels, 30 seconds/sample (FMM read time) | Depedent on LC separation |
| Light Source | 830 nm, fiber-coupled diode laser | Inquire | 660 nm laser, programmable 10% - 100% of maximum power. |
| Applications | Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactions | Inquire | With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. |
| Get Quote | | | |