Particle Size Analyzer (Particle Analyzers / Particle Sizer)

Particle analyzers are used to determine the size and distribution of particles making up a material. Particle size analyzers are used in numerous fields for research and development, manufacturing and for quality control and product testing. Different technologies enable analysis across a wide range of sizes, of particles in powder, liquid, aerosol or other forms, and of materials ranging in diversity from soil, paint and cosmetics to nasal spray and proteins.

Laser diffraction particle size analyzers calculate particle size from the angle of light scattered by a stream of particles passing through a laser beam. This technique allows for continuous measurement of bulk material across a wide size range (10 nm to 3 mm). The size limits and sensitivity of a laser diffraction particle analyzer depend on the number and placement of detectors in the instrument. Dynamic light scattering particle analyzers are mainly used for analyzing particles in solution (size range: 1 nm to 6 um). Dynamic light scattering determines size from the fluctuations in scattered laser light intensity created by the particles’ Brownian motion. Induced grating particle size analyzers identify the size of even smaller particles (0.5 nm to 200 nm) in solutions by electrically aligning the particles and then measuring their diffusion.

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CompanyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt Technology
ItemminiDAWN™ Multi-Angle Light Scattering (MALS) Detector for SEC-MALSDynaPro Plate Reader 4 Dynamic Light Scattering InstrumentDynaPro™ ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering Instrument
Citations
(4)
Catalog NumberminiDAWNDynaPro Plate Reader 4DynaPro ZetaStar
Price
DescriptionCouple the miniDAWN™ to your favorite HPLC or FPLC to determine the absolute molar masses and sizes of macromolecules and nanoparticles in solution from hundreds to millions of Daltons—without the need for column calibration standards. This sensitive unit requires as little as 25 ng injected ... Read MoreThe DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply ... Read MoreUnique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Automate measurements of zeta potential and size for up to 96 samples at a time ... Read More
TypeMALS and optional DLSDynamic Light Scattering / Static Light ScatteringDynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Static Light Scattering (SLS)
Particle SizeInquire0.5 to 1000 nm0.2 to 1000 nm
Detector(s)High-gain, high-dynamic range photodiodes at 3 detection angles for MALS. Optional avalanche photodiode for simultaneous dynamic light scattering measurements.Linearized avalanche photodiode for dynamic and static light scatteringInquire
Measuring TimeDepedent on LC separationMeasurement Time: 5 to 60 seconds per well
830 nm
15 seconds typical
Light Source658 nm laser, programmable from 10% to 100% maximum power.830 nm, fiber-coupled diode laser785 nm laser, programmable 10% to 100%
ApplicationsWith SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. With Calypso CG-MALS: characterization of biomolecular interactions.Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactionsAnalysis of proteins, gene vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, nano-emulsions, lipid and metallic nanoparticles, and more.
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