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| Company | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | miniDAWN™ Multi-Angle Light Scattering (MALS) Detector for SEC-MALS | Aura PTx System Particle Analyzers | microDAWN™ Multi-Angle Light Scattering Instrument for UHP-SEC-MALS |
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| Catalog Number | miniDAWN | Aura PTx | microDAWN |
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| Description | Couple the miniDAWN™ to your favorite HPLC or FPLC to determine the absolute molar masses and sizes of macromolecules and nanoparticles in solution from hundreds to millions of Daltons—without the need for column calibration standards. This sensitive unit requires as little as 25 ng injected Couple the miniDAWN™ to your favorite HPLC or FPLC to determine the absolute molar masses and sizes of macromolecules and nanoparticles in solution from hundreds to millions of Daltons—without the need for column calibration standards. This sensitive unit requires as little as 25 ng injected sample, 100 kDa polystyrene in THF (varies for other samples and solvents). The miniDAWN is engineered with self-contained modules that are easily replaced making it field serviceable. The system-ready monitors soise levels in real-time and an all-green status indicator lets you know when your system is ready for data collection. The optional DLS module uses the WyattQELS™ module, which fits inside the miniDAWN to providing on-line dynamic light scattering for determining radii down to 0.5 nm. All light scattering cells are subject to contamination by particles and to combat this issue the instrument has a self-cleaning, embedded COMET™ ultrasonic module. For maximum reliability and uptime, program the miniDAWN to automatically clean the cell after every run. The units may also be combined with a Calypso™ composition-gradient system to characterize biomolecular interactions.... Read More | Accelerate protein formulation development and screening for therapeutic drug development
Protein stability analysis and preventing aggregation are is crucial when developing therapies. That’s why it’s time to leave flow cell imaging behind.
Speed up protein formulation development and screening Accelerate protein formulation development and screening for therapeutic drug development
Protein stability analysis and preventing aggregation are is crucial when developing therapies. That’s why it’s time to leave flow cell imaging behind.
Speed up protein formulation development and screening with Aura PTx. With just 5 µL of a sample, discover a faster way to detect, count and characterize excipients and drug products at earlier stages of therapeutic development.
Now you can quickly identify and count aggregates that form due to degraded polysorbate in your formulation. And with two-channel fluorescence, determine if aggregation in your protein therapy is caused by proteins or polysorbates in your sample – at the same time.
Features:- Learn more with innovative technology. Aura PTx System combines backgrounded membrane imaging (BMI) with two channels of fluorescence membrane microscopy (FMM) to give you protein aggregate data without the need to clean between measurements.
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ID protein aggregates. Accurately detect excipient degradation within your formulations and distinguish between protein and non-protein particles effortlessly.
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Monitor polysorbate degradation. With fluorescence applications, you can track polysorbate degradation to confidently evaluate the stability of your product.
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Analyze small volumes. You only need 5 µL of sample, allowing you to start characterizing protein aggregates earlier in development.
... Read More | The microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size andThe microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and concentrations. In most respects, the microDAWN is similar to the well-established miniDAWN, a workhorse MALS instrument used in hundreds of labs around the world for characterizing proteins and other molecules smaller than 50 nm in radius. The microDAWN is uniquely suitable for use in conjunction with UHPLC Size Exclusion Chromatography (µSEC-MALS) thanks to its small interdetector dispersion and produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC. In some cases it may be used with ion-exchange or other types of chromatography.... Read More |
| Type | MALS and optional DLS | Inquire | MALS and optional DLS |
| Particle Size | Inquire | >1 µm (ECD) to <5 mm (ECD) | Inquire |
| Detector(s) | High-gain, high-dynamic range photodiodes at 3 detection angles for MALS. Optional avalanche photodiode for simultaneous dynamic light scattering measurements. | Inquire | High-gain, high dynamic range, static light scattering detectors at 3 angles |
| Measuring Time | Depedent on LC separation | 1 minute/sample (BMI read time). 3 FL channels, 30 seconds/sample (FMM read time) | Depedent on LC separation |
| Light Source | 658 nm laser, programmable from 10% to 100% maximum power. | Inquire | 660 nm laser, programmable 10% - 100% of maximum power. |
| Applications | With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. With Calypso CG-MALS: characterization of biomolecular interactions. | Inquire | With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. |
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