Particle Size Analyzer (Particle Analyzers / Particle Sizer)

Particle analyzers are used to determine the size and distribution of particles making up a material. Particle size analyzers are used in numerous fields for research and development, manufacturing and for quality control and product testing. Different technologies enable analysis across a wide range of sizes, of particles in powder, liquid, aerosol or other forms, and of materials ranging in diversity from soil, paint and cosmetics to nasal spray and proteins.

Laser diffraction particle size analyzers calculate particle size from the angle of light scattered by a stream of particles passing through a laser beam. This technique allows for continuous measurement of bulk material across a wide size range (10 nm to 3 mm). The size limits and sensitivity of a laser diffraction particle analyzer depend on the number and placement of detectors in the instrument. Dynamic light scattering particle analyzers are mainly used for analyzing particles in solution (size range: 1 nm to 6 um). Dynamic light scattering determines size from the fluctuations in scattered laser light intensity created by the particles’ Brownian motion. Induced grating particle size analyzers identify the size of even smaller particles (0.5 nm to 200 nm) in solutions by electrically aligning the particles and then measuring their diffusion.

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CompanyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt Technology
ItemminiDAWN™ Multi-Angle Light Scattering (MALS) Detector for SEC-MALSDAWN™ Multi-angle Light Scattering (MALS) InstrumentDynaPro™ ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering Instrument
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Catalog NumberminiDAWNDAWNDynaPro ZetaStar
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DescriptionCouple the miniDAWN™ to your favorite HPLC or FPLC to determine the absolute molar masses and sizes of macromolecules and nanoparticles in solution from hundreds to millions of Daltons—without the need for column calibration standards. This sensitive unit requires as little as 25 ng injected ... Read MoreThe DAWN™ instrument is an advanced detector for precise characterization of proteins, polymers, and nanoparticles including viral vectors, lipid nanoparticles and vesicles. Using multi-angle static light scattering (MALS) and optional dynamic light scattering (DLS), DAWN analyzes molar mass... Read MoreUnique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Automate measurements of zeta potential and size for up to 96 samples at a time ... Read More
TypeMALS and optional DLSMALS and optional DLSDynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Static Light Scattering (SLS)
Particle SizeInquireInquire0.2 to 1000 nm
Detector(s)High-gain, high-dynamic range photodiodes at 3 detection angles for MALS. Optional avalanche photodiode for simultaneous dynamic light scattering measurements.High-gain, high-dynamic-range photodiodes at 18 angles for MALS; optional avalanche photodiode that may be placed at any of four angles for DLS.
Fluorescence-blocking filters available for use with analytes that fluoresce when illuminated at the MALS wavelength.
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Measuring TimeDepedent on LC separationDepedent on LC separation15 seconds typical
Light Source658 nm laser, programmable from 10% to 100% maximum power.658 nm laser, programmable 10% - 100% of maximum power.

Optional: 785 nm for fluorescence suppression
785 nm laser, programmable 10% to 100%
ApplicationsWith SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. With Calypso CG-MALS: characterization of biomolecular interactions.With standard SEC/GPC or EclipseTM (FFF system): determination of distributions of molar mass, size, conformation, conjugation ratio and particle concentration. With Calypso composition-gradient system: label-free characterization of biomolecular interactions including self- and hetero-association as well as non-specific interactions.Analysis of proteins, gene vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, nano-emulsions, lipid and metallic nanoparticles, and more.
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