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| Company | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | Aura+ System Particle Analyzers | DynaPro Plate Reader 4 Dynamic Light Scattering Instrument | microDAWN™ Multi-Angle Light Scattering Instrument for UHP-SEC-MALS |
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| Catalog Number | Aura+ | DynaPro Plate Reader 4 | microDAWN |
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| Description | Fast, decisive, low-volume particle characterization analysis for biotherapeutic workflows
When you need the flexibility to conduct particle characterization analyses on different types of biologics, including protein and antibody therapeutics, cell therapies, and gene therapies, the Aura+ System Fast, decisive, low-volume particle characterization analysis for biotherapeutic workflows
When you need the flexibility to conduct particle characterization analyses on different types of biologics, including protein and antibody therapeutics, cell therapies, and gene therapies, the Aura+ System has you covered.
Fully configured to support applications across protein, antibody, cell, and gene therapy workflows, Aura+ brings particle characterization to earlier stages of therapeutic development, so you can make better decisions sooner.
Powered by the backgrounded membrane imaging (BMI) and fluorescence membrane microscopy (FMM) technology shared within the Aura family of instruments, Aura+ System enables applications from late discovery to development and manufacturing, enhancing decision-making and accelerating your success.
Features:- Save precious material with just 5 µL sample volume requirements
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Get actionable results from a full 96 well plate of labeled samples to data in just 90 minutes
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Boost efficiency with 96-well membrane plate high-throughput capability
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Gain deeper particle insights with advanced imaging
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Rely only on one platform for proteins, antibodies, and cell and gene therapies development
... Read More | The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply load and walk away. Measurements are completed in standard 96, 384 or 1536 disposable well plates and the instrument can be integrated with plate and liquid-handling robots for additional time savings.... Read More | The microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size andThe microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and concentrations. In most respects, the microDAWN is similar to the well-established miniDAWN, a workhorse MALS instrument used in hundreds of labs around the world for characterizing proteins and other molecules smaller than 50 nm in radius. The microDAWN is uniquely suitable for use in conjunction with UHPLC Size Exclusion Chromatography (µSEC-MALS) thanks to its small interdetector dispersion and produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC. In some cases it may be used with ion-exchange or other types of chromatography.... Read More |
| Type | Inquire | Dynamic Light Scattering / Static Light Scattering | MALS and optional DLS |
| Particle Size | Range from >1 µm (ECD) to <5 mm (ECD) | 0.5 to 1000 nm | Inquire |
| Detector(s) | Inquire | Linearized avalanche photodiode for dynamic and static light scattering | High-gain, high dynamic range, static light scattering detectors at 3 angles |
| Measuring Time | 1 minute/sample (BMI read time). 3 FL channels, 30 seconds/sample (FMM read time) | Measurement Time: 5 to 60 seconds per well 830 nm | Depedent on LC separation |
| Light Source | Inquire | 830 nm, fiber-coupled diode laser | 660 nm laser, programmable 10% - 100% of maximum power. |
| Applications | Inquire | Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactions | With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. |
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