| Description | Accelerate protein formulation development and screening for therapeutic drug development
Protein stability analysis and preventing aggregation are is crucial when developing therapies. That’s why it’s time to leave flow cell imaging behind.
Speed up protein formulation development and screening Accelerate protein formulation development and screening for therapeutic drug development
Protein stability analysis and preventing aggregation are is crucial when developing therapies. That’s why it’s time to leave flow cell imaging behind.
Speed up protein formulation development and screening with Aura PTx. With just 5 µL of a sample, discover a faster way to detect, count and characterize excipients and drug products at earlier stages of therapeutic development.
Now you can quickly identify and count aggregates that form due to degraded polysorbate in your formulation. And with two-channel fluorescence, determine if aggregation in your protein therapy is caused by proteins or polysorbates in your sample – at the same time.
Features:- Learn more with innovative technology. Aura PTx System combines backgrounded membrane imaging (BMI) with two channels of fluorescence membrane microscopy (FMM) to give you protein aggregate data without the need to clean between measurements.
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ID protein aggregates. Accurately detect excipient degradation within your formulations and distinguish between protein and non-protein particles effortlessly.
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Monitor polysorbate degradation. With fluorescence applications, you can track polysorbate degradation to confidently evaluate the stability of your product.
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Analyze small volumes. You only need 5 µL of sample, allowing you to start characterizing protein aggregates earlier in development.
... Read More | Fast, decisive, low-volume AAV characterization for gene therapy development workflows
Adeno-associated viruses (AAVs) have revolutionized gene therapy product development. With limited material available, allocating valuable samples for aggregate testing may have seemed impractical—until now.
AuraFast, decisive, low-volume AAV characterization for gene therapy development workflows
Adeno-associated viruses (AAVs) have revolutionized gene therapy product development. With limited material available, allocating valuable samples for aggregate testing may have seemed impractical—until now.
Aura GT System is the first and only system designed to detect, count, and characterize AAV particles with just 5 µL. Combining backgrounded membrane imaging (BMI) with fluorescence membrane microscopy (FMM) dual-channel technology, confident decisions can be made earlier—one step closer to success.
Analyze small volumes. Only 5 µL of sample is needed, allowing particle characterization in early phase development.
Characterize and identify viral vectors. Aura GT System distinguishes between capsid and non-capsid aggregates and enables you to confirm whether DNA leakage is the root cause of aggregation straight from the box.
Gain deeper gene therapy understanding. Gain insight with Aura GT System’s duo of BMI and FMM, which distinguish and characterize different serotypes for aggregation and product features for deeper understanding of gene therapy – without tedious, labor-intensive assays.
Features:- Characterize AAV, lentivirus, and other viral vectors across key applications like aggregation and stability.
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Detect, count, and characterize AAV particles with just 5 µL of sample. Identify capsid and DNA aggregates in your gene therapy sample with confidence.
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Make direct comparisons between different formulations, AAV serotypes, storage conditions, and lots.
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Detect and count particles from 1 µm up to 5 mm.
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Save time with measurements under one minute per sample.
... Read More | The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply load and walk away. Measurements are completed in standard 96, 384 or 1536 disposable well plates and the instrument can be integrated with plate and liquid-handling robots for additional time savings.... Read More |
| Measuring Time | 1 minute/sample (BMI read time). 3 FL channels, 30 seconds/sample (FMM read time) | 1 minute/sample (BMI read time). 3 FL channels, 30 seconds/sample (FMM read time) | Measurement Time: 5 to 60 seconds per well
830 nm |