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| Company | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | Aura GT System Particle Analyzers | DynaPro Plate Reader 4 Dynamic Light Scattering Instrument | omniDAWN™ Multi-angle Light Scattering (MALS) Instrument |
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| Catalog Number | Aura GT | DynaPro Plate Reader 4 | omniDAWN |
| Price | | | |
| Description | Fast, decisive, low-volume AAV characterization for gene therapy development workflows
Adeno-associated viruses (AAVs) have revolutionized gene therapy product development. With limited material available, allocating valuable samples for aggregate testing may have seemed impractical—until now.
AuraFast, decisive, low-volume AAV characterization for gene therapy development workflows
Adeno-associated viruses (AAVs) have revolutionized gene therapy product development. With limited material available, allocating valuable samples for aggregate testing may have seemed impractical—until now.
Aura GT System is the first and only system designed to detect, count, and characterize AAV particles with just 5 µL. Combining backgrounded membrane imaging (BMI) with fluorescence membrane microscopy (FMM) dual-channel technology, confident decisions can be made earlier—one step closer to success.
Analyze small volumes. Only 5 µL of sample is needed, allowing particle characterization in early phase development.
Characterize and identify viral vectors. Aura GT System distinguishes between capsid and non-capsid aggregates and enables you to confirm whether DNA leakage is the root cause of aggregation straight from the box.
Gain deeper gene therapy understanding. Gain insight with Aura GT System’s duo of BMI and FMM, which distinguish and characterize different serotypes for aggregation and product features for deeper understanding of gene therapy – without tedious, labor-intensive assays.
Features:- Characterize AAV, lentivirus, and other viral vectors across key applications like aggregation and stability.
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Detect, count, and characterize AAV particles with just 5 µL of sample. Identify capsid and DNA aggregates in your gene therapy sample with confidence.
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Make direct comparisons between different formulations, AAV serotypes, storage conditions, and lots.
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Detect and count particles from 1 µm up to 5 mm.
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Save time with measurements under one minute per sample.
... Read More | The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply The DynaPro Plate Reader 4 is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply load and walk away. Measurements are completed in standard 96, 384 or 1536 disposable well plates and the instrument can be integrated with plate and liquid-handling robots for additional time savings.... Read More | Delivering up to 4× faster runs with half the sample, the omniDAWN™ multi-angle static light scattering (MALS) photometer is purpose-built for UPLC™ and UHPLC systems for non-destructive absolute molar mass and size characterization of macromolecules and nanoparticles in solution. It provides Delivering up to 4× faster runs with half the sample, the omniDAWN™ multi-angle static light scattering (MALS) photometer is purpose-built for UPLC™ and UHPLC systems for non-destructive absolute molar mass and size characterization of macromolecules and nanoparticles in solution. It provides exceptional sensitivity across a broad range of molecular weights, sizes, and concentrations, supported by advanced analysis modules, practical implementation guides, and intelligent system health monitoring to ensure reliable performance and streamlined workflows.... Read More |
| Type | Inquire | Dynamic Light Scattering / Static Light Scattering | Multi-Angle Light Scattering (MALS) photometer |
| Particle Size | Range from >1 µm (ECD) to <5 mm (ECD) | 0.5 to 1000 nm | Inquire |
| Detector(s) | Inquire | Linearized avalanche photodiode for dynamic and static light scattering | Inquire |
| Measuring Time | 1 minute/sample (BMI read time). 3 FL channels, 30 seconds/sample (FMM read time) | Measurement Time: 5 to 60 seconds per well 830 nm | Inquire |
| Light Source | Inquire | 830 nm, fiber-coupled diode laser | Inquire |
| Applications | Inquire | Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactions | With standard SEC/GPC or EclipseTM (FFF system): determination of distributions of molar mass, size, conformation, conjugation ratio, and particle concentration. With the Calypso composition-gradient system: label-free characterization of biomolecular interactions, including self- and hetero-association as well as non-specific interactions. |
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