Particle Size Analyzer (Particle Analyzers / Particle Sizer)

Particle analyzers are used to determine the size and distribution of particles making up a material. Particle size analyzers are used in numerous fields for research and development, manufacturing and for quality control and product testing. Different technologies enable analysis across a wide range of sizes, of particles in powder, liquid, aerosol or other forms, and of materials ranging in diversity from soil, paint and cosmetics to nasal spray and proteins.

Laser diffraction particle size analyzers calculate particle size from the angle of light scattered by a stream of particles passing through a laser beam. This technique allows for continuous measurement of bulk material across a wide size range (10 nm to 3 mm). The size limits and sensitivity of a laser diffraction particle analyzer depend on the number and placement of detectors in the instrument. Dynamic light scattering particle analyzers are mainly used for analyzing particles in solution (size range: 1 nm to 6 um). Dynamic light scattering determines size from the fluctuations in scattered laser light intensity created by the particles’ Brownian motion. Induced grating particle size analyzers identify the size of even smaller particles (0.5 nm to 200 nm) in solutions by electrically aligning the particles and then measuring their diffusion.

Find, compare, and request a quote for particle size analyzers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.

CompanyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt Technology
ItemDynaPro™ Plate Reader III Dynamic Light Scattering InstrumentDAWN™ Multi-angle Light Scattering (MALS) InstrumentDynaPro™ NanoStar™ II Dynamic Light Scattering InstrumentDynaPro™ ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering InstrumentmicroDAWN™ Multi-Angle Light Scattering Instrument for UHP-SEC-MALS
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Catalog NumberDynaPro Plate reader IIIDAWNDynaPro NanoStar IIDynaPro ZetaStarmicroDAWN
Price
DescriptionThe DynaPro™ Plate Reader III is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions ... Read MoreThe DAWN™ instrument is an advanced detector for precise characterization of proteins, polymers, and nanoparticles including viral vectors, lipid nanoparticles and vesicles. Using multi-angle static light scattering (MALS) and optional dynamic light scattering (DLS), DAWN analyzes molar mass... Read MoreThe DynaPro™ NanoStar™ II is the only DLS instrument to provide a fully integrated, walk-up measurement experience so even novices can immediately measure particle concentration, characterize size, aggregation, quality solubility, and stability of proteins, viruses, or nanoparticles in ... Read MoreUnique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flow... Read MoreThe microDAWN™ MALS detector performs absolute characterization of macromolecules eluting from UHPLC (or UPLC), determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and... Read More
TypeDynamic Light Scattering / Static Light ScatteringMALS and optional DLSDynamic Light Scattering (DLS) and Static Light Scattering (SLS)Dynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Static Light Scattering (SLS)MALS and optional DLS
Particle Size0.5 to 1000 nmInquire0.2 to 1000 nm0.2 to 1000 nmInquire
Detector(s)Linearized avalanche photodiode for dynamic and static light scatteringHigh-gain, high-dynamic-range photodiodes at 18 angles for MALS; optional avalanche photodiode that may be placed at any of four angles for DLS.
Fluorescence-blocking filters available for use with analytes that fluoresce when illuminated at the MALS wavelength.
InquireInquireHigh-gain, high dynamic range, static light scattering detectors at 3 angles
Measuring TimeMeasurement Time: 5 to 60 seconds per well
830 nm
Depedent on LC separationInquire15 seconds typicalDepedent on LC separation
Light Source830 nm, fiber-coupled diode laser658 nm laser, programmable 10% - 100% of maximum power.

Optional: 785 nm for fluorescence suppression
Inquire785 nm laser, programmable 10% to 100%660 nm laser, programmable 10% - 100% of maximum power.
ApplicationsDevelop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactionsWith standard SEC/GPC or EclipseTM (FFF system): determination of distributions of molar mass, size, conformation, conjugation ratio and particle concentration. With Calypso composition-gradient system: label-free characterization of biomolecular interactions including self- and hetero-association as well as non-specific interactions.InquireAnalysis of proteins, gene vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, nano-emulsions, lipid and metallic nanoparticles, and more.With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio.
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