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| Company | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | DynaPro™ ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering Instrument | DynaPro™ NanoStar™ II Dynamic Light Scattering Instrument | DynaPro™ Plate Reader III Dynamic Light Scattering Instrument | miniDAWN™ Multi-Angle Light Scattering (MALS) Detector for SEC-MALS | WyattQELS™ Light Scattering Detector Module |
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| Catalog Number | DynaPro ZetaStar | DynaPro NanoStar II | DynaPro Plate reader III | miniDAWN | WyattQELS |
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| Description | Unique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flowUnique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flow cell. Quickly quantify size, polydispersity, zeta potential/charge, particle concentration, molar mass or turbidity for characterization and stability studies.
Key Features:
- DYNAMICS™ Touch on-board app for walk-up, self-guided operation
- Adaptive collection for faster and simpler measurements of zeta potential
- Measure size and turbidity with just 2 µL of solution, or zeta potential with as little as 65 µL of solution
- Measure zeta potential in buffers with conductivity up to 2x physiological saline
- A selection of high-quality quartz and disposable cells and cuvettes for both size and zeta potential measurements
... Read More | The DynaPro™ NanoStar™ II is the only DLS instrument to provide a fully integrated, walk-up measurement experience so even novices can immediately measure particle concentration, characterize size, aggregation, quality solubility, and stability of proteins, viruses, or nanoparticles in The DynaPro™ NanoStar™ II is the only DLS instrument to provide a fully integrated, walk-up measurement experience so even novices can immediately measure particle concentration, characterize size, aggregation, quality solubility, and stability of proteins, viruses, or nanoparticles in solution.
Key Features:
- DYNAMICS™, touch on-board app for walk-up, self-guided operation
- Measure size and size distributions with just 2 µL of solution of solution
- Measure macromolecules molecular weight from 300 Da to 1 MDa
... Read More | The DynaPro™ Plate Reader III is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions The DynaPro™ Plate Reader III is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions - simply load and walk away. Measurements are completed in standard 96, 384 or 1536 disposable well plates and the instrument can be integrated with plate and liquid-handling robots for additional time savings.... Read More | Couple the miniDAWN™ to your favorite HPLC or FPLC to determine the absolute molar masses and sizes of macromolecules and nanoparticles in solution from hundreds to millions of Daltons—without the need for column calibration standards. This sensitive unit requires as little as 25 ng injected Couple the miniDAWN™ to your favorite HPLC or FPLC to determine the absolute molar masses and sizes of macromolecules and nanoparticles in solution from hundreds to millions of Daltons—without the need for column calibration standards. This sensitive unit requires as little as 25 ng injected sample, 100 kDa polystyrene in THF (varies for other samples and solvents). The miniDAWN is engineered with self-contained modules that are easily replaced making it field serviceable. The system-ready monitors soise levels in real-time and an all-green status indicator lets you know when your system is ready for data collection. The optional DLS module uses the WyattQELS™ module, which fits inside the miniDAWN to providing on-line dynamic light scattering for determining radii down to 0.5 nm. All light scattering cells are subject to contamination by particles and to combat this issue the instrument has a self-cleaning, embedded COMET™ ultrasonic module. For maximum reliability and uptime, program the miniDAWN to automatically clean the cell after every run. The units may also be combined with a Calypso™ composition-gradient system to characterize biomolecular interactions.... Read More | The WyattQELS™ dynamic light scattering (DLS) module integrates into a DAWN™, miniDAWN™ or microDAWN™ online multi-angle light scattering (MALS) instrument in order to determine high-resolution particle size distributions, when used in conjunction with a separation technique The WyattQELS™ dynamic light scattering (DLS) module integrates into a DAWN™, miniDAWN™ or microDAWN™ online multi-angle light scattering (MALS) instrument in order to determine high-resolution particle size distributions, when used in conjunction with a separation technique such as size exclusion chromatography (SEC) or Eclipse™, field-flow fractionation (FFF). The measurement is performed at exactly the same time and in the same sample volume as MALS so Rh and Rg can be compared for particle conformation insights.
Applications include the characterization of the conformation of polymers and biomolecules, detection of protein unfolding, and identification of nanoparticles and vesicles based on shape and structure. One can also use QELS insights to determine optimal chromatography conditions based on molecular conformation.... Read More |
| Type | Dynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Static Light Scattering (SLS) | Dynamic Light Scattering (DLS) and Static Light Scattering (SLS) | Dynamic Light Scattering / Static Light Scattering | MALS and optional DLS | Dynamic Light Scattering |
| Particle Size | 0.2 to 1000 nm | 0.2 to 1000 nm | 0.5 to 1000 nm | Inquire | Flow mode: 1 nm to 40 nm (TREOS); 1 nm to 300 (HELEOS)
Batch mode: 10 to 50 nm; 0.5 nm to 1 µm (cut 10 to 50 nm) |
| Detector(s) | Inquire | Inquire | Linearized avalanche photodiode for dynamic and static light scattering | High-gain, high-dynamic range photodiodes at 3 detection angles for MALS. Optional avalanche photodiode for simultaneous dynamic light scattering measurements. | Avalanche photodiode coupled to a multimode optical fiber |
| Measuring Time | 15 seconds typical | Inquire | Measurement Time: 5 to 60 seconds per well
830 nm | Depedent on LC separation | Measurement Time: 0.1 to 3600 sec
Same as MALS host instrument |
| Light Source | 785 nm laser, programmable 10% to 100% | Inquire | 830 nm, fiber-coupled diode laser | 658 nm laser, programmable from 10% to 100% maximum power. | Uses the host MALS instrument's laser, usually a 658 nm laser. |
| Applications | Analysis of proteins, gene vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, nano-emulsions, lipid and metallic nanoparticles, and more. | Inquire | Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactions | With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. With Calypso CG-MALS: characterization of biomolecular interactions. | High-resolution size distributions with fractionation by SEC or FFF; conformation when combined with MALS molar mass and/or size data |
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