| Description | Method scouting is a process where different mobile phases and column stationary phases are evaluated to determine the best set of separation conditions for a particular sample. Manual solvent preparation, column switching, and method programming are time-consuming steps, so the Nexera method Method scouting is a process where different mobile phases and column stationary phases are evaluated to determine the best set of separation conditions for a particular sample. Manual solvent preparation, column switching, and method programming are time-consuming steps, so the Nexera method scouting system was developed to streamline the entire process for more efficient method development.
The system is based around 2 LC-30AD pumps, each with a quaternary valve, which allows the analyst to run binary gradients with 16 different solvent pairs. A high-pressure column selection valve holds from 1 to 6 columns, resulting in up to 96 unique separation conditions per sample. Ultra-high speed conditions can be easily transferred to conventional conditions using a transfer program. In addition, scouting is performed automatically when the mobile phase is switched.
The Nexera Method Scouting Solution software has intuitive, user-friendly screens to set the pump and column valve positions, gradient program steps, and it automatically builds the sequence table in seconds. Method Scouting Solution provides the data required for analysis via a graphical user interface, as well as automated controls conforming to laboratory operations configured in the system settings.
... Read More | Automatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system’s on-line preAutomatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system’s on-line pre-treatment of bio-samples reduces labor while enhancing efficiency. A high-throughput autosampler provides high-speed injection and reproducibility. Accurate and precise temperature control of the system further ensures reproducible analysis and a high recovery rate. Key features include: - Shim-pack MAYI-ODS Pretreatment Column – This unique column effectively removes proteins from bio-samples, achieves long-term stability through optimization of particle diameter and newly developed coating technology, and exhibits excellent repeatability
- On-line Dilution Bypass Effect – Eliminates the need for preliminary dilution of the sample by automatically diluting it on-line, leading to excellent recovery rates
- Suppression of Carryover – A number of enhancements, including a specially treated outer needle surface and improvement of needle seal composition, greatly reduce sample adsorption, critical for achieving the high sensitivity of LC-MS/MS
- Precise Temperature Control of the Pretreatment Column
This system serves as a front-end HPLC system for a mass spectrometer, enhancing the efficiency of analyzing drugs in bio-samples in pharmacokinetics studies and clinical tests. ... Read More | The Shimadzu Cannabis Analyzer for Potency captures the spirit of an Analyzer – a comprehensive package integrating instrument hardware, software, consumables, and analytical workflow. Includes a certified reference material (CRM) mixture of target compounds. Also includes a service package to coverThe Shimadzu Cannabis Analyzer for Potency captures the spirit of an Analyzer – a comprehensive package integrating instrument hardware, software, consumables, and analytical workflow. Includes a certified reference material (CRM) mixture of target compounds. Also includes a service package to cover preventive maintenance and warranty for three years, plus free technical support for the life of the product. The solution is ready to use after one day of installation and testing, and requires no time-consuming method development on the part of the analyst.
Choice of three proven HPLC methods: - High Throughput HPLC Method Package – Designed for analysis of the 10 most commonly requested cannabinoids in under 8 minutes. This is the original method developed by Shimadzu in collaboration with industry laboratories. (Does not include THCV.)
- High Sensitivity HPLC Method Package – Adds THCV to the target analyte list, with an instrument cycle time of under 10 minutes. The short analysis time produces the sharpest chromatographic peaks for the best overall sensitivity.
- High Resolution HPLC Method Package – Presents full baseline resolution for all 11 compounds and an analysis time under 30 minutes. This method is preferred for research purposes, or when additional compounds must be added to the analysis in response to new state regulatory requirements.
... Read More | Built for fast and accurate sample analysis, the latest iteration of Shimadzu’s compact, robust integrated (U)HPLC system maintains the excellent core performance capabilities of its predecessor while incorporating innovative functionality to drive productivity and ensure high-quality analytical Built for fast and accurate sample analysis, the latest iteration of Shimadzu’s compact, robust integrated (U)HPLC system maintains the excellent core performance capabilities of its predecessor while incorporating innovative functionality to drive productivity and ensure high-quality analytical results.
Features include:
- Excellent baseline stability with advanced optical temperature control
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High-capacity oven with precise temperature control
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Ultra-fast 14-second injection cycle achievable
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Outstanding reproducibility and linearity with near zero carryover
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UV or PDA detector standard; optional detectors, including single LCMS, can be added
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Auto validation function
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Optimized method development when combined with LabSolutions MD software
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Easy-to-use, easy-access front-panel interface replicates the system flow channel and simplifies the operating status of the system
The new i-Series incorporates multiple automated functions that simplify workflows and enable higher work efficiency, such as:
- Automated flow rate control
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Mobile phase monitoring
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Automatic detection & correction of air bubbles
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Automated method development
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Automated peak identification
Maintenance reminders, remote operation and monitoring, and a new intelligent column management tool, which tracks column usage and performance, help to maintain analytical robustness and deliver consistent, reliable results for all users.... Read More | The modular LC-40 system is the workhorse for everyday HPLC, whether using traditional 5 micron fully porous LC columns or the popular SPP column phases for high efficiency separations with lower back pressures. With Analytical Intelligence functions, the system makes lab management simple, enablingThe modular LC-40 system is the workhorse for everyday HPLC, whether using traditional 5 micron fully porous LC columns or the popular SPP column phases for high efficiency separations with lower back pressures. With Analytical Intelligence functions, the system makes lab management simple, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
Key features and benefits include: - High efficiency chromatography with 44 MPa (~6,000 psi) pressure tolerance and LPGE or HPGE solvent delivery
- Ultra-fast injection cycles (7 sec) with ultralow carryover
- High capacity sample handling
- Optional dual-injection system
- Outstanding baseline stability and linearity (2.5 AU), even under fluctuating temperatures
- Plate changers enable non-stop temperature-controlled analysis of thousands of samples
- Allows remote monitoring in real time directly from a web browser or smart device
- Touch-panel interface allows the user to control the instrument and carry out analysis preparation directly without the need for a PC
- Analytical intelligence functions, including smart flow control, automatic startup, auto-recovery and auto-diagnostics, and real-time mobile phase monitoring
- i-PeakFinder tool – can automatically recognize peaks even in complex chromatograms with high noise, and accounts for baseline drift for higher integration accuracy
- i-PDeA II peak deconvolution function – can quantify peaks that cannot be completely separated by a column
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