Chemicals are used in laboratories around the globe for a seemingly endless array of experimental and investigative procedures including those in chemistry, biochemistry, cellular biology, and molecular biology. Some categories of chemicals include Acids and Bases, Reagents, Adhesives, Solvents, Buffers, Flammable Liquids and more.
Lab chemicals are vast and can vary in grade, concentration, or consistency in accordance with their intended applications. Chemical grades include ACS Grade (USP and NF are ACS equivalencies), Reagent Grade, Laboratory Grade, and Technical grade.
Explore and compare laboratory chemicals across leading suppliers at Labcompare; including access to product citations and first-hand reviews from our scientific community.
|  | | | | |
| Company | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation |
| Item | LXE408 | 3-Formyl-4-isopropoxyphenylboronic acid (contains varying amounts of Anhydride) | 4-(1H-Pyrazol-1-ylsulfonyl)phenylboronic acid | Boc-(S)-3-Amino-3-phenylpropanal | ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate |
| Catalog Number | L647581 | F165774 | H188741 | B190695 | E176394 |
| Price | Supplier Page | Supplier Page | Supplier Page | Supplier Page | Supplier Page |
| Description | LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 has an IC 50 of 0.04 µM for L. donovani proteasome and an EC 50 of 0.04 µM for L. donovani. LXE408 has a low propensity to cross the blood brain barrier. LXE408 has the potential for LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 has an IC 50 of 0.04 µM for L. donovani proteasome and an EC 50 of 0.04 µM for L. donovani. LXE408 has a low propensity to cross the blood brain barrier. LXE408 has the potential for visceral leishmaniasis (VL) research.In VitroLXE408 (compound 1) can occupy the pocket as a ternary complex with the proteasome. LXE408 shows no inhibition of the hERG channel (IC 50 >30 µM) in a manual patch clamp assay. LXE408 has a low propensity to cross the blood brain barrier (brain/plasma AUC ratio=0.03 in mice). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoLXE408 (compound 1; 0.3-10 mg/kg; PO; twice daily for 8 days) potently reduces the parasite burden in the liver in a dose-dependent manner. LXE408 (1, 3, 10, 20 mg/kg; p.o.; b.i.d.; for 10 days) effects robust healing of parasite-induced skin lesions at the base of the tail in BALB/c mice infected with L. major. LXE408 (5 mg/kg IV and 20 mg/kg PO) has a T 1/2 of 3.3 hours for mouse. LXE408 (3 mg/kg IV and 10 mg/kg PO) has a T 1/2 of 3.8 hours, a CL of 2.1 mL/min•kg, and a V ss of 0.53 L/kg for male Sprague-Dawley rat. LXE408 (0.3 mg/kg IV and 1.0 mg/kg PO) has a T 1/2 of 3.8 hours for male beagle dog. LXE408 (0.3 mg/kg IV and 10 mg/kg PO) has a T 1/2 of 9.7 hours for male cynomolgus monkey. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c mice (6-8 weeks old) infected with L. donovani Dosage: 0.3, 1, 3, 10 mg/kg Administration: PO; twice daily for 8 days Result: Led to a 95% and >99.84% reduction of parasite burden in the liver at 1 mg/kg and 10 mg/kg. Animal Model: Balb/C mice Dosage: 5 mg/kg IV and 20 mg/kg PO (Pharmacokinetic Analysis) Administration: IV or PO Result: Had a T 1/2 of 3.3 hours, a CL of 2.3 mL/min•kg, and a V ss of 0.63 L/kg for mouse.Form:Solid... Read More | Inquire | Inquire | Inquire | Inquire |
| Quantity | 5mg, 10mg | 250mg, 5g, 1g | 250mg, 1g | 100mg, 10g, 25mg, 250mg, 1g, 5g | 5g, 1g |
| Type | Chelating Agents & Ligands | Organic Compound | Chemical | Chemical | Aromatic Compound, Chemical |
| Format | Inquire | Inquire | Inquire | Inquire | Solid |
| Purity / Grade | ≥99% | ≥95% | ≥98% | ≥97% | ≥97% |
| SMILES | CC1=C(N=CC=C1)C2=CN3C(=NC(=N3)C4=C(C=CC(=C4)NC(=O)C5=C(N=C(O5)C)C)F)N=C2 | B(C1=CC(=C(C=C1)OC(C)C)C=O)(O)O | B(C1=CC=C(C=C1)S(=O)(=O)N2C=CC=N2)(O)O | CC(C)(C)OC(=O)N[C@@H](CC=O)C1=CC=CC=C1 | CCOC(=O)C1=C(C2=CC=CC=C2NC1=O)O |
| Molecular Formula | C23H18FN7O2 | C10H13BO4 | C9H9BN2O4S | C14H19NO3 | C12H11NO4 |
| Applications | Inquire | Inquire | Inquire | Inquire | Inquire |
| Get Quote | Supplier Page | Supplier Page | Supplier Page | Supplier Page | Supplier Page |