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| Company | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation |
| Item | α-Methyl-DL-phenylalanine | Gymnoside VII | N-(4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}phenyl)acetamide | Poly divinylbenzene porous beads GDX-101 | Seltorexant hydrochloride |
| Catalog Number | M166002 | G664361 | N668366 | P116962 | S656195 |
| Price | Supplier Page | Supplier Page | Supplier Page | Supplier Page | Supplier Page |
| Description | Inquire | Inquire | Inquire | Inquire | Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist ( pK i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brainIn Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist ( pK i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brainIn VivoSeltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats. The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (350-450 g) Dosage: 30 mg/kg Administration: p.o.; per day for 7 days Result: The reduced sleep onset (non–rapid eye movement (NREM) latency) and the increased NREM sleep duration were maintained upon 7-day repeated dosing with JNJ-42847922. The prolongation of NREM sleep time was due to a significant increase in NREM bout duration throughout the treatment period assessed on D1 and D7. Rapid eye movement (REM) sleep was only marginally affected on D4 of treatment, resulting in a small but significant reduction in REM sleep latency and an increase in REM sleep duration.IC50& Target:human OX2R 8.0 (pKi) rat OX2R 8.1 (pKi)... Read More |
| Quantity | 250mg, 5g, 1g | 10mg | 5mg, 1mg | 5g, 25g | 1ml |
| Type | Chelating Agents & Ligands | Chelating Agents & Ligands | Chelating Agents & Ligands | Chemical | Chelating Agents & Ligands |
| Purity / Grade | %Moligand™, ≥98, %%%≥98, Moligand™, ≥98, Moligand™, ≥98, %≥98 | ≥98% | Inquire | 40-60 mesh | 10mM in DMSO |
| SMILES | CC(CC1=CC=CC=C1)(C(=O)O)N | Inquire | CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2C3=CN=CC=C3 | Inquire | Inquire |
| Molecular Formula | C10H13NO2 | Inquire | C18H21N3O3S | Inquire | C21H23ClFN7O |
| Applications | Inquire | Inquire | Inquire | Inquire | Inquire |
| Get Quote | Supplier Page | Supplier Page | Supplier Page | Supplier Page | Supplier Page |