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| ![β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE](https://media.labcompare.com/m/1/vendor/107976-400x300.jpg "β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE") | | | | |
| Company | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation | Aladdin Scientific Corporation |
| Item | β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE | 1-(4-bromopyrazol-1-yl)cyclopropanecarboxylic acid | CL-387785 | Methyl 2-amino-5-bromobenzoate | Pyrazine |
| Catalog Number | G1372126 | C631193 | C337834 | M133876 | P109614 |
| Price | Supplier Page | Supplier Page | Supplier Page | Supplier Page | Supplier Page |
| Description | β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects... Read More | Inquire | CL-387,785 irreversibly inhibits EGF-receptor (EGFR) kinase activity as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR. CL-387,785 also blocks EGF-mediated growth in A431 cells. The compound inhibits proliferation of EGFR or c-ErbB2 expressing cells by covalently bindingCL-387,785 irreversibly inhibits EGF-receptor (EGFR) kinase activity as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR. CL-387,785 also blocks EGF-mediated growth in A431 cells. The compound inhibits proliferation of EGFR or c-ErbB2 expressing cells by covalently binding to the EGFR... Read More | Inquire | Inquire |
| Quantity | 1mg | 100mg, 250mg, 5g, 500mg, 1g | 100mg, 500mg | 100g, 5g, 10g, 25g | 100g, 50g, 500g, 10g |
| Type | Bioactive Small Molecules | Organic Compound | Chelating Agents & Ligands | Organic Compound | Organic Compound |
| Purity / Grade | Inquire | ≥97% | ≥97% | ≥98% | ≥98% |
| SMILES | Inquire | C1CC1(C(=O)O)N2C=C(C=N2)Br | CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br | COC(=O)C1=C(C=CC(=C1)Br)N | C1=CN=CC=N1 |
| Molecular Formula | Inquire | C7H7N2O2Br | C18H13BrN4O | C8H8BrNO2 | C4H4N2 |
| Applications | Inquire | Inquire | Inquire | Inquire | Inquire |
| Get Quote | Supplier Page | Supplier Page | Supplier Page | Supplier Page | Supplier Page |