Dynamic light scattering particle size analyzers are used to measure the size of very small particles (0.6 nm to 6 um) in solution. This class of particle size analyzer interprets particles’ sizes from the fluctuations in scattered laser light created by the particles’ Brownian motion. Dynamic light scattering analysis is used in medical, biological research and materials science applications, and is also known as photon correlation spectroscopy or quasi-electron light scattering.
Although requiring suspension in a solution, particle size analysis by dynamic light scattering offers the advantage of measuring particles across a wide range of densities, from parts-per-million up to 40% of solution. Other advantages include size analysis of particles in their native environment and micro-liter scale minimum sample sizes. In addition, dynamic light scattering particle size analyzers may also provide information on particle shape and require less user training. Analysis times typically vary from 30 seconds to 2 minutes per sample.
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| Company | Entegris | Entegris | Entegris | Entegris |
| Item | Nicomp N3000 | Mini DLS System | Nicomp N3000 Nanoparticle Size Analyzer | Nicomp N3000 Online System |
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| Catalog Number | | Mini DLS System | N3000 | NO300 |
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| Description | Inquire | Nanoparticles are now standard materials for many industrial products. Like most other processes, the production of nano-particles needs to be measured in order to be controlled. Dynamic light scattering (DLS) measurements have traditionally been performed using laboratory instruments like the Nanoparticles are now standard materials for many industrial products. Like most other processes, the production of nano-particles needs to be measured in order to be controlled. Dynamic light scattering (DLS) measurements have traditionally been performed using laboratory instruments like the Entegris Nicomp system, but the Entegris particle sizing team also has many years of online experience. The Mini DLS builds on these years of experience to develop a flexible and elegant solution that can be adapted to a wide range of nanoparticle manufacturing processes including milling, homogenizing, or self-assembly.
On-line particle size analyzer for nanoparticles and emulsions from 20 nm to 2 µm
- Flexible protocols to optimize measurement to application based on dynamic light scattering (DLS)
- Automated sampling and measurement to eliminate operator and lab resources
- Continuous data to track changes in particle size distribution
- Easy data transfer to process monitoring control software
... Read More | The Nicomp dynamic light scattering (DLS) system measures size and zeta potential of nano sized particles from 0.3 nm to 10 µm. The backbone of the Nicomp DLS system is a proprietary high resolution multimodal deconvolution algorithm that can resolve close bimodal distributions. More The Nicomp dynamic light scattering (DLS) system measures size and zeta potential of nano sized particles from 0.3 nm to 10 µm. The backbone of the Nicomp DLS system is a proprietary high resolution multimodal deconvolution algorithm that can resolve close bimodal distributions. More importantly, it can separate the native peak of a distribution from the aggregate tail allowing researchers to determine the size of the native population. This is a critical parameter when trying to develop materials where the native population is directly responsible for the final properties of a product.
The Nicomp DLS instrumentation is engineered using a modular design approach. This allows for semi customization of the instruments based on the customers application needs.
Standard Nicomp Features
- Nicomp high resolution multi modal algorithm.
- Baseline adjust for automatic aggregate compensation.
- Multiple sample cells including a 1 cm cuvette and 6mm culture tubes that are low volume and can be centrifuged to remove contaminates.
- Time history plot provides a visual display of when adequate scattering data is collected to ensure statistically valid results.
- Vesicle Weighting – provides a light scattering correction for analysis of unilamellar vesicles.
Optional Features
- Patented Autodilution – eliminates the need for manual dilution of concentrated samples up to 40% solids. Provides more precise dilutions to the optimal measuring concentration resulting in higher reproducibility. It is the enabling technology for automation; batch autosampler and online measurements.
- Multi-Angle Goniometer – utilizes a precision stepper motor coupled with an optical fiber to provide multi angle sizing from approximately 12 – 175 degrees. Ideal for advanced users with complex distributions in the Mie regime that are looking to focus in on parts of their distribution.
- High Power Laser Diodes – 15 – 100 mW red, 20 – 100 mW green provide adequate scattering for ultra-small particles below 20 nm and low scattering materials avoiding without the need to compromise the measurement by over concentrating the sample which leads to multiple scattering and particle interaction effects.
- Avalanche Photo Diode Detector – provides a high sensitivity detector for low concentration and low scattering samples. Up to 7× gain over a standard photomultiplier tube and when coupled with a higher power laser diode enables accurate sizing information for sub 1 nm particles.
- Low Volume Cells – index matched sample cells for analysis of samples volumes down to 10 microliters. Ideal for expensive protein and macromolecules used in life science applications.
- Autosampler/Online – by incorporating the auto dilution feature in the Nicomp which can handle samples with up to 40% solids, the measurement can be extended into a batch auto sampler platform for automated QC analysis of up to 96 samples
... Read More | Dynamic light scattering (DLS) is the most prevalent size analysis technique for nanoparticles. Although the vast majority of DLS size measurements are performed in the laboratory, the nanotechnology revolution has created higher demand for online DLS systems and the Nicomp® Online is a proven Dynamic light scattering (DLS) is the most prevalent size analysis technique for nanoparticles. Although the vast majority of DLS size measurements are performed in the laboratory, the nanotechnology revolution has created higher demand for online DLS systems and the Nicomp® Online is a proven industrial solution. Our Nicomp online system allows users to monitor a manufacturing process to ensure a high quality product without waste.
Nicomp N3000 Online System
- Using dynamic light scattering (DLS) technology, this online system couples a compact optics bench with our unique autodilution fluidics, all rugged enough for the production environment
- Autodilution allows even concentrated materials like paint to be monitored
- Special trending graphs in the software can be used to set out-of-control (OOC) limits that will signal operations when the end point is reached
- The system is small enough to be integrated with many nanoparticle processes, providing real-time particle size distributions
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| Type | Dynamic Light Scattering (DLS) | Inquire | Dynamic Light Scattering | Dynamic Light Scattering |
| Particle Size | 0.3 nm to 10 µm | Inquire | Inquire | Inquire |
| Detector(s) | PMT (standard); APD (optional) | Inquire | 15 – 100 mW red laser diodes, 20 – 100 mW green laser diodes | PMT standard, optional 7X gain APD |
| Measuring Time | ~2 minutes | Inquire | Inquire | Inquire |
| Light Source | 12 mW red laser diode (standard); optional 15, 35, 50, 100 mW red or 50, 100 mW green | Inquire | Inquire | Inquire |
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