Dynamic light scattering particle size analyzers are used to measure the size of very small particles (0.6 nm to 6 um) in solution. This class of particle size analyzer interprets particles’ sizes from the fluctuations in scattered laser light created by the particles’ Brownian motion. Dynamic light scattering analysis is used in medical, biological research and materials science applications, and is also known as photon correlation spectroscopy or quasi-electron light scattering.
Although requiring suspension in a solution, particle size analysis by dynamic light scattering offers the advantage of measuring particles across a wide range of densities, from parts-per-million up to 40% of solution. Other advantages include size analysis of particles in their native environment and micro-liter scale minimum sample sizes. In addition, dynamic light scattering particle size analyzers may also provide information on particle shape and require less user training. Analysis times typically vary from 30 seconds to 2 minutes per sample.
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| Company | Waters | Wyatt Technology | Waters | Wyatt Technology |
| Item | Calypso™ Biomolecular Interaction System | DynaPro™ ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering Instrument |
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| Catalog Number | Calypso II | DynaPro ZetaStar |
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| Description | The Calypso™ composition-gradient system and CALYPSO™ software combine with a DAWNTM or miniDAWN™ MALS instrument to characterize biomolecular interactions by CG-MALS. CG-MALS is a label-free, immobilization-free technique that measures the change in apparent molecular weight withThe Calypso™ composition-gradient system and CALYPSO™ software combine with a DAWNTM or miniDAWN™ MALS instrument to characterize biomolecular interactions by CG-MALS. CG-MALS is a label-free, immobilization-free technique that measures the change in apparent molecular weight with composition and concentration in order probe protein-protein binding and other interactions.
Calypso’s unique software analyzes self- and hetero-association, non-specific interactions(both attractive and repulsive), reversible and irreversible kinetics of aggregation and dissociation A comprehensive variety of interaction parameters including equilibrium dissociation constants, absolute complex stoichiometry, virial coefficients (A2) and cross-virial coefficients (A11), and reaction rates can be determined using CG-MALS.... Read More | Unique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Automate measurements of zeta potential and size for up to 96 samples at a time Unique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Automate measurements of zeta potential and size for up to 96 samples at a time or measure manually with cuvettes with the walk-up touch screen functionality for optimal efficiency. Quickly quantify size, polydispersity, zeta potential/charge, particle concentration, molar mass or turbidity for characterization and stability studies.
Key Features:
- DYNAMICS™ Touch on-board app for walk-up, self-guided operation
- Pairable with a Waters HPLC and Pump to automate measurements of zeta potential and size
- Flow Mode for best-in-class zeta potential reproducibility and precision for samples in high salt buffers or prone to degradation
- Adaptive collection for faster and simpler measurements of zeta potential
- Measure size and turbidity with just 2 µL of solution, or zeta potential with as little as 65 µL of solution
- A selection of high-quality quartz and disposable cells and cuvettes for both size and zeta potential measurements
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| Type | Composition-Gradient Multi-Angle Light Scattering (CG-MALS) | Dynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Static Light Scattering (SLS) |
| Particle Size | Inquire | 0.2 to 1000 nm |
| Detector(s) | Inquire | Inquire |
| Measuring Time | 30 minutes to 10 hours; 1 hour typical | 15 seconds typical |
| Light Source | Inquire | 785 nm laser, programmable 10% to 100% |
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