| Quantity | ~0.6x10^6 cells per 1ml of freezing medium (vial) | 5 slides | 1.5 million cells & Neural Plating-XF Medium | 2 vials | 20 nmol, 50 nmol, 100 nmol, 200 nmol |
| Description | iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. The analysis of cell respiration directly reflects the health and function of mitochondria.
iNeuO2™-Rapid cells can be used as a control for all products containing iNeuO2™ biosensor. In order to customize iNeuRapid™ cells according to the experimental needs of scientists, these cells can be easily transfected with the target gene. For other human cell lines and human cell types, please contact us.... Read More | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | The product SIRGT34137WQ-LNA is a type of small interfering RNA (siRNA) that targets NFE2L3 gene and regulates the expression of gene. The siRNA interferes with the expression of NFE2L3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The The product SIRGT34137WQ-LNA is a type of small interfering RNA (siRNA) that targets NFE2L3 gene and regulates the expression of gene. The siRNA interferes with the expression of NFE2L3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is systematically modified with the synthetic RNA-like high affinity nucleotide analogue, Locked Nucleic Acid (LNA), to improve its bio-stability, specificity and efficiency. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |