| Description | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. The analysis of cell respiration directly reflects the health and function of mitochondria.
iNeuO2™-Rapid cells can be used as a control for all products containing iNeuO2™ biosensor. In order to customize iNeuRapid™ cells according to the experimental needs of scientists, these cells can be easily transfected with the target gene. For other human cell lines and human cell types, please contact us.... Read More | This product GTVCR-WQ39MR is an effective transcription system suitable for a variety of research, including the in vitro translation, self-amplifying mRNA studies and protein expression. The system was driven by the T7 promoter to efficiently generate mRNA with 30 nt poly(A) tail ecoding antibody This product GTVCR-WQ39MR is an effective transcription system suitable for a variety of research, including the in vitro translation, self-amplifying mRNA studies and protein expression. The system was driven by the T7 promoter to efficiently generate mRNA with 30 nt poly(A) tail ecoding antibody which targeting VEGFA. The vector contains the self-replicating Venezuelan equine encephalitis (VEE) virus RNA replicon, which resulting the mRNA expression at a high level.... Read More | Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the axon membrane to the extracellular space (myelin sheath space) at the Raniver node allows the action potential to propagate quickly along the axon. RSC is important for the morphology, survival and growth of axons and neurons. Studies have also shown that Schwann cells can promote neuronal recovery and experimental spinal cord regeneration.... Read More |