| Description | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. The analysis of cell respiration directly reflects the health and function of mitochondria.
iNeuO2™-Rapid cells can be used as a control for all products containing iNeuO2™ biosensor. In order to customize iNeuRapid™ cells according to the experimental needs of scientists, these cells can be easily transfected with the target gene. For other human cell lines and human cell types, please contact us.... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | Streptococcus is a genus of Gram-positive coccus that belongs to the family Streptococcaceae, within the order Lactobacillales. Streptococcus thermophilus is a powerful probiotic strain that has well researched health benefits. This probiotic is often found in the colon and has many digestive, Streptococcus is a genus of Gram-positive coccus that belongs to the family Streptococcaceae, within the order Lactobacillales. Streptococcus thermophilus is a powerful probiotic strain that has well researched health benefits. This probiotic is often found in the colon and has many digestive, immunity and many other researched health benefits.... Read More |