| Description | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey ovarian tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey ovarian tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More | Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from normal Cynomolgus monkey prostate tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from normal Cynomolgus monkey prostate tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More | Creative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability andCreative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability and maturation of sensory neurons for endpoint assays on glass or plastic.
Our iPSC-derived sensory neurons express several voltage-gated sodium ion channels and transient receptor potential (TRP) ion channels that play a key role in nociception. These include sodium ion channels Nav1.7 and the DRG-specific, TTX-resistant channels, Nav1.8 and Nav1.9 as well as the temperature-sensitive, TRPV1 and TRPM8, and TRPA1, a sensor of pungency, bitterness and cold.
Creative Biolabs iPSC-Derived Sensory Neuron Progenitors are available in large batch sizes for reliable and consistent results in high-throughput screening assays. The cells are also suitable for investigating disorders of the peripheral nervous system and chronic pain as well as drug targets for pain relief.... Read More | Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the axon membrane to the extracellular space (myelin sheath space) at the Raniver node allows the action potential to propagate quickly along the axon. RSC is important for the morphology, survival and growth of axons and neurons. Studies have also shown that Schwann cells can promote neuronal recovery and experimental spinal cord regeneration.... Read More |