| Description | This product is a 51.1 kDa Human RXFP3 membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh bone marrow under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh bone marrow under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of applications, including drug discovery, assay validation/development, and immunology based assays.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Creative Biolabs offers the overexpression HEK293 cells stably expressing additional TLR or NOD genes. | The product SIRGT47166WQ-2F is a type of small interfering RNA (siRNA) that targets LIN28A gene and regulates the expression of gene. The siRNA interferes with the expression of LIN28A gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The The product SIRGT47166WQ-2F is a type of small interfering RNA (siRNA) that targets LIN28A gene and regulates the expression of gene. The siRNA interferes with the expression of LIN28A gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2_-deoxy-2_-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |