| Description | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey lymph node tissue.Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey lymph node tissue.Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | This product GTTS-WQ11760MR is a type of mRNA having 30 nt poly(A) tail and modified with Cap 0 & Pseudo-UTP. It ecodes the monoclonal antibody that targets CTLA4 gene. The antibody can be applied in Solid tumors research. | The product SIRGT95067WQ is a type of small interfering RNA (siRNA) that targets Coq4 gene and regulates the expression of gene. The siRNA interferes with the expression of Coq4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT95067WQ is a type of small interfering RNA (siRNA) that targets Coq4 gene and regulates the expression of gene. The siRNA interferes with the expression of Coq4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |