| Description | Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey intestinal mesenteric vascular tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of testsCynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey intestinal mesenteric vascular tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More | Human astrocytes (HA) are derived from the human cerebral cortex. Astrocytes are the most abundant cells in the central nervous system, where they perform many functions, such as providing mechanical support and nutrition to neurons and removing waste from neurons. Provide signals to endothelial Human astrocytes (HA) are derived from the human cerebral cortex. Astrocytes are the most abundant cells in the central nervous system, where they perform many functions, such as providing mechanical support and nutrition to neurons and removing waste from neurons. Provide signals to endothelial cells; regulate neurogenesis and control synaptic function. With the increasing understanding of the importance of astrocytes in the nervous system, HA has become a useful in vitro model for exploring the functional diversity of astrocytes.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Marmoset monkeys are tree-dwelling small monkeys that habitat South American. This product is isolated from Marmosets Brain Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitationMarmoset monkeys are tree-dwelling small monkeys that habitat South American. This product is isolated from Marmosets Brain Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | The product SIRGT45322WQ is a type of small interfering RNA (siRNA) that targets KIAA0319L gene and regulates the expression of gene. The siRNA interferes with the expression of KIAA0319L gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It The product SIRGT45322WQ is a type of small interfering RNA (siRNA) that targets KIAA0319L gene and regulates the expression of gene. The siRNA interferes with the expression of KIAA0319L gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |