| Quantity | 20 nmol, 50 nmol, 100 nmol, 200 nmol | 1.5 million cells & Neural Plating-XF Medium | 1mg | Inquire | 20 nmol, 50 nmol, 100 nmol, 200 nmol |
| Description | The product SIRGT35687WQ is a type of small interfering RNA (siRNA) that targets SARM1 gene and regulates the expression of gene. The siRNA interferes with the expression of SARM1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT35687WQ is a type of small interfering RNA (siRNA) that targets SARM1 gene and regulates the expression of gene. The siRNA interferes with the expression of SARM1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | This product is a 65.8 kDa Human DSG3 membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | Ruminococcus is a genus of bacteria in the class Clostridia. They are anaerobic, Gram-positive gut microbes. One or more species in this genus are found in significant numbers in the human gut microbiota. | The product SIRGT00060WQ is a type of small interfering RNA (siRNA) that targets ADA gene and regulates the expression of gene. The siRNA interferes with the expression of ADA gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potentialThe product SIRGT00060WQ is a type of small interfering RNA (siRNA) that targets ADA gene and regulates the expression of gene. The siRNA interferes with the expression of ADA gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |