| Description | This product is a 33.9 kDa Human MC2R membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | iNeuMito™ is a mitochondrial calcium biosensor that responds in the fluorescence range of 605nm-625nm (excitation/emission: 610nm / 625nm) and has been integrated into iNeuRapid™, iNeu's proprietary immortalized human cell line. iNeuMito™-Rapid cells can be used as a control for iNeuMito™ is a mitochondrial calcium biosensor that responds in the fluorescence range of 605nm-625nm (excitation/emission: 610nm / 625nm) and has been integrated into iNeuRapid™, iNeu's proprietary immortalized human cell line. iNeuMito™-Rapid cells can be used as a control for all products containing iNeuMito™ biosensor.... Read More | Marmoset monkeys are tree-dwelling small monkeys that habitat South American. This product is isolated from Marmosets Brain Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitationMarmoset monkeys are tree-dwelling small monkeys that habitat South American. This product is isolated from Marmosets Brain Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | This product is a 10.4 kDa native human C5a protein isolated from normal human serum. It is availible for Functional Assays, ELISA, RIA. |