| Description | The product SIRGT10498WQ is a type of small interfering RNA (siRNA) that targets KRAS gene and regulates the expression of gene. The siRNA interferes with the expression of KRAS gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT10498WQ is a type of small interfering RNA (siRNA) that targets KRAS gene and regulates the expression of gene. The siRNA interferes with the expression of KRAS gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | African Green Monkey has long been one of the most important non-human primate models for biomedical research which is close to Rhesus monkey. This product is isolated from African Green Monkeys Endocrine Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be usedAfrican Green Monkey has long been one of the most important non-human primate models for biomedical research which is close to Rhesus monkey. This product is isolated from African Green Monkeys Endocrine Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | This product is a Human LAMP5 membrane protein expressed in HEK293. | This product is a 34 kDa recombinant human Complement C7 protein Antigen with a N-terminal His6-ABP tag expressed in the E.coli. It is available for Antibody Competition. |