| Description | The product SIRGT10498WQ is a type of small interfering RNA (siRNA) that targets KRAS gene and regulates the expression of gene. The siRNA interferes with the expression of KRAS gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT10498WQ is a type of small interfering RNA (siRNA) that targets KRAS gene and regulates the expression of gene. The siRNA interferes with the expression of KRAS gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh bone marrow under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh bone marrow under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of applications, including drug discovery, assay validation/development, and immunology based assays.... Read More | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to humans anatomically and physiologically. This product is collected from Rhesus monkey Veins or arteries tissue. The sample is negative for Herpes B Virus, Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to humans anatomically and physiologically. This product is collected from Rhesus monkey Veins or arteries tissue. The sample is negative for Herpes B Virus, retroviruses, SIV, SRV, & STLV. It can be applied for life science laboratory or biochemical experiment such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More |