| Quantity | 5 vials | 5 slides | 1.5 million cells & Neural Plating-XF Medium | 20 nmol, 50 nmol, 100 nmol, 200 nmol | 20 nmol, 50 nmol, 100 nmol, 200 nmol |
| Description | The liposome is composed of L-alpha-Phosphatidylcholine, Cholesterol and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) (65:30:5). The mean particle size is 100 nm. | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | The product SIRGT73619WQ-2MOE is a type of small interfering RNA (siRNA) that targets PET100 gene and regulates the expression of gene. The siRNA interferes with the expression of PET100 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The The product SIRGT73619WQ-2MOE is a type of small interfering RNA (siRNA) that targets PET100 gene and regulates the expression of gene. The siRNA interferes with the expression of PET100 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2'-O-methoxyethyl (2'-MOE) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | The product SIRGT00054WQ is a type of small interfering RNA (siRNA) that targets ACVR2A gene and regulates the expression of gene. The siRNA interferes with the expression of ACVR2A gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT00054WQ is a type of small interfering RNA (siRNA) that targets ACVR2A gene and regulates the expression of gene. The siRNA interferes with the expression of ACVR2A gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |