| Description | The product SIRGT76066WQ-2OMe is a type of small interfering RNA (siRNA) that targets ATL1 gene and regulates the expression of gene. The siRNA interferes with the expression of ATL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNAThe product SIRGT76066WQ-2OMe is a type of small interfering RNA (siRNA) that targets ATL1 gene and regulates the expression of gene. The siRNA interferes with the expression of ATL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2_-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Chimpanzees are social animals most closely related to the human, they could be used in biomedical research repeatedly over decades. This product is isolated from Chimpanzees Epidermis Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of Chimpanzees are social animals most closely related to the human, they could be used in biomedical research repeatedly over decades. This product is isolated from Chimpanzees Epidermis Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh peripheral blood mononuclear cell under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh peripheral blood mononuclear cell under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of studies in immunology, infectious diseases, cancer therapy, etc.... Read More | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More |