| Description | The hippocampus is important for memory formation and is severely affected in the brain of Alzheimer's disease (AD). When used in AD models, both APP and the atypical PS1 variant HS showed increased Aβ42/Aβ40 peptide ratio and decreased synaptic protein levels, which are common features ofThe hippocampus is important for memory formation and is severely affected in the brain of Alzheimer's disease (AD). When used in AD models, both APP and the atypical PS1 variant HS showed increased Aβ42/Aβ40 peptide ratio and decreased synaptic protein levels, which are common features of AD. However, these two variants differ in terms of tau hyperphosphorylation, protein aggregation and protein network changes. NeuroD1-mediated gene therapy in HSD-derived progenitor cells can regulate the expression of many genes, including genes related to synaptic transmission. Therefore, HS can be used to reveal the underlying mechanism of early pathogenic changes in the hippocampus of AD patients and provide a powerful platform for the development of treatment strategies for early AD.
Creative Biolabs's Human iPSC-Derived Hippocampal Spheroids are derived from induced pluripotent stem cells (iPSC) without integration under fully defined neural induction conditions.
Creative Biolabs's Human iPSC-Derived Hippocampal Spheroids are rich in hippocampal neurons and express zinc finger and BTB domain-containing protein 20 (ZBTB20) and Prospero homeobox protein 1 (PROX1). In addition, the hippocampal neurons derived from the APP variant HS exhibit profound transcriptome changes, which can be regulated by the overexpression of NeuroD1 (ND1), leading to the upregulation of genes whose gene products are related to synaptic transmission and are altered in AD.... Read More | Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, convex, and translucent. Some species of Lactobacillus used commonly as probiotics. They are most commonly used for diarrhea, including infectious diarrhea and diarrhea in people taking antibiotics. Some people also use lactobacillus for general digestion problems, irritable bowel syndrome; IBS, colic in infants, and many other conditions that involve the stomach and bowel.... Read More | Rabbit corneal epithelial cells (RbCEpC) are isolated from rabbit corneal epithelial tissue, which covers and protects the cornea from bacteria and other harmful organisms and substances. RbCEpC is cryopreserved in the X generation, and is cultivated and propagated at least when the X population hasRabbit corneal epithelial cells (RbCEpC) are isolated from rabbit corneal epithelial tissue, which covers and protects the cornea from bacteria and other harmful organisms and substances. RbCEpC is cryopreserved in the X generation, and is cultivated and propagated at least when the X population has doubled.... Read More | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Spleen Tissue. The sample is negative for Herpes-B Virus, as well asRhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Spleen Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | The product SIRGT70081WQ is a type of small interfering RNA (siRNA) that targets NSL1 gene and regulates the expression of gene. The siRNA interferes with the expression of NSL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT70081WQ is a type of small interfering RNA (siRNA) that targets NSL1 gene and regulates the expression of gene. The siRNA interferes with the expression of NSL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |