| Description | The product SIRGT73211WQ-2MOE is a type of small interfering RNA (siRNA) that targets PCDHB5 gene and regulates the expression of gene. The siRNA interferes with the expression of PCDHB5 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The The product SIRGT73211WQ-2MOE is a type of small interfering RNA (siRNA) that targets PCDHB5 gene and regulates the expression of gene. The siRNA interferes with the expression of PCDHB5 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2'-O-methoxyethyl (2'-MOE) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Researchers at the Creative Biolabs have developed C57BL/6 Mouse Irradiated Splenocytes that allows for study in numerous research areas, such as immunology, oncology. The cells can be used for a wide variety of safety assessment and functional assays. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | This product is a 21.4kDa recombinant mouse Ficolin 2 protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB. | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Ovary Tissue. The sample is negative for Herpes-B Virus, as well as Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Ovary Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More |